LAMR1 Mouse anti-Human, Clone: 5D4, Bioss

Description

• Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes
• They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis
• Many of the effects of laminin are mediated through interactions with cell surface receptors
• These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins
• This gene encodes a high-affinity, non-integrin family, laminin receptor 1
• This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein
• The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function
• It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts
• Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype
• Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events
• Two alternatively spliced transcript variants encoding the same protein have been found for this gene.