beta Adducin Rabbit anti-Human, Polyclonal, Bioss

Description

• Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma
• The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues
• While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues
• Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta
• Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension
• Heterodimers consisting of alpha and gamma subunits have also been described
• Structurally, each subunit is comprised of two distinct domains
• The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive
• The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin
• Various adducin beta mRNAs, alternatively spliced at 3′end and/or internally spliced and encoding different isoforms, have been described
• The functions of all the different isoforms are not known.