Home Products Antibodies Primary Antibodies 50 198 3760
50-198-3760

HCST Rabbit anti-Human, Polyclonal, Bioss

Manufacturer: Bioss

Select a Size

Pack Size SKU Availability Price
Each of 1 50-198-3760-Each-of-1 In Stock ₹ 36,897.75

50-198-3760 - Each of 1

₹ 36,897.75

In Stock

Quantity

1

Base Price: ₹ 36,897.75

GST (18%): ₹ 6,641.595

Total Price: ₹ 43,539.345

Antigen

HCST

Classification

Polyclonal

Conjugate

Unconjugated

Gene

HCST

Gene Symbols

HCST

Immunogen

KLH conjugated synthetic peptide derived from human HCST.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Applications

Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot

Concentration

1 μg/mL

Formulation

PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH

Gene Accession No.

Q9UBK5

Host Species

Rabbit

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

10870

Content And Storage

-20°C

Form

Liquid

Related Products

Img

Bioss

50-198-3756

--

Img

Bioss

50-198-3731

--

Img

Bioss

50-198-3906

--

Img

Bioss

50-198-3599

--

Img

Bioss

50-198-3377

--

Img

Bioss

50-198-3395

--

Img

Bioss

50-198-3708

--

Img

Bioss

50-198-3065

--

Description

  • Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation
  • Functions as docking site for PI3-kinase PIK3R1 and GRB2
  • Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways
  • Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells
  • In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors
  • In T-cells, it provides primarily costimulation for TCR-induced signals
  • KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.

Compare Similar Items

Show Difference

Img

Bioss

50-198-3760

--

Antigen:
HCST
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HCST
Gene Symbols:
HCST
Immunogen:
KLH conjugated synthetic peptide derived from human HCST.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.:
Q9UBK5
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
10870
Content And Storage:
-20°C
Form:
Liquid

Img

Bioss

50-198-3761

--

Antigen:
HDDC2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Hddc2
Gene Symbols:
Hddc2
Immunogen:
KLH conjugated synthetic peptide derived from human HDDC2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.:
Q7Z4H3
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
51020
Content And Storage:
-20°C
Form:
Liquid

Img

Bioss

50-198-3762

--

Antigen:
HDGFL1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HDGFL1
Gene Symbols:
HDGFL1
Immunogen:
KLH conjugated synthetic peptide derived from human HDGFL1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.:
Q5TGJ6
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
154150
Content And Storage:
-20°C
Form:
Liquid

Img

Bioss

50-198-3763

--

Antigen:
HDHD1A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PUDP
Gene Symbols:
PUDP
Immunogen:
KLH conjugated synthetic peptide derived from human HDHD1A.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 μg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.:
Q08623
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
8226
Content And Storage:
-20°C
Form:
Liquid