HPV33 E6 Rabbit anti-Human, Polyclonal, Bioss

Description

• Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer
• HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types
• Approximately 90% of cervical cancers contain HPV DNA of the high risk types
• Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function
• The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications
• The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro
• Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa
• Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae
• However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer
• The E6 protein is a transcriptional transactivator
• Binds double-stranded DNA
• This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).