Adenovirus 5 E1A Rabbit anti-Human, Polyclonal, Bioss

Description

• Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e
• common colds)
• 49 human adenovirus serotypes have been discovered and divided into six subgroups, A to E, based on observation
• They are an important cause of respiratory illness, conjunctivitis, gastroenteritis, and have more recently been recognized as a potential cause of sexually transmitted diseases
• Several types have oncogenic potential though most cause self-limiting febrile illnesses characterized by inflammation of conjunctivae and the respiratory tract
• The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections
• It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods
• In patients experiencing immunosuppression (e.g
• AIDS) it can be reactivated, causing disease
• Adenovirus vectors, particularly those based on Ad5, have shown great promise for the development of gene therapy protocols and have been used for clinical purpose
• The early region (E1A) of the adenovirus genome plays a central role in cellular transformation and regulation of gene expression
• The E1A region encodes a series of related proteins (35-46kDa) with multifuctional capabilities and form a specific complex with the retinoblastoma tumor suppressor gene product (Rb protein)
• The E1A and E1B regions together comprise the transforming region of adenovirus
• While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region
• Several conserved regions of E1A are similar to portions of other viral oncoproteins like the HPV-16 and HPV-18 E7 and SV40 large T antigen.