50-198-9953
Caspase 8 Mouse anti-Human, Clone: 4G12, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-9953-Each-of-1 | In Stock | ₹ 45,440.92 |
50-198-9953 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,440.92
GST (18%): ₹ 8,179.366
Total Price: ₹ 53,620.286
Antigen
Caspase 8
Classification
Monoclonal
Concentration
1 μg/mL
Formulation
TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.
Q14790
Gene Symbols
Casp8
Immunogen
Recombinant human Caspase 8 Protein.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
4G12
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B; Apoptotic cysteine protease; Apoptotic protease Mch-5; BOS_1957; CAP4; Casp8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; Caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
841
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Compare Similar Items
Show Difference
Antigen: Caspase 8
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.: Q14790
Gene Symbols: Casp8
Immunogen: Recombinant human Caspase 8 Protein.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: 4G12
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B; Apoptotic cysteine protease; Apoptotic protease Mch-5; BOS_1957; CAP4; Casp8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; Caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 841
Content And Storage: -20°C
Form: Liquid
Antigen:
Caspase 8
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.:
Q14790
Gene Symbols:
Casp8
Immunogen:
Recombinant human Caspase 8 Protein.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
4G12
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B; Apoptotic cysteine protease; Apoptotic protease Mch-5; BOS_1957; CAP4; Casp8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; Caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
841
Content And Storage:
-20°C
Form:
Liquid
Antigen: HSP27
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.: P04792
Gene Symbols: HSPB1
Immunogen: Recombinant human HSP27 Protein.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: 1G12
Conjugate: Unconjugated
Gene: HSPB1
Gene Alias: 27kDa; 28 kDa heat shock protein; CMT2F; DKFZp586P1322; epididymis secretory protein Li 102; Estrogen-regulated 24 kDa protein; Growth-related 25 kDa protein; Heat shock 25 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; heat shock protein 1; heat shock protein 27 kDa beta-1; heat shock protein B1; Heat shock protein beta-1; heat shock protein family B (small) member 1; heat shock protein, 25 kDa; HEL-S-102; HMN2B; HS; HS.76067; HSP; HSP 25; HSP 27; Hsp25; HSP27; HSP28; HSPB1; p25; Phospho-HSP 27; SRP27; Stress-responsive protein 27; truncated hsp25
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 3315
Content And Storage: -20°C
Form: Liquid
Antigen:
HSP27
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.:
P04792
Gene Symbols:
HSPB1
Immunogen:
Recombinant human HSP27 Protein.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
1G12
Conjugate:
Unconjugated
Gene:
HSPB1
Gene Alias:
27kDa; 28 kDa heat shock protein; CMT2F; DKFZp586P1322; epididymis secretory protein Li 102; Estrogen-regulated 24 kDa protein; Growth-related 25 kDa protein; Heat shock 25 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; heat shock protein 1; heat shock protein 27 kDa beta-1; heat shock protein B1; Heat shock protein beta-1; heat shock protein family B (small) member 1; heat shock protein, 25 kDa; HEL-S-102; HMN2B; HS; HS.76067; HSP; HSP 25; HSP 27; Hsp25; HSP27; HSP28; HSPB1; p25; Phospho-HSP 27; SRP27; Stress-responsive protein 27; truncated hsp25
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
3315
Content And Storage:
-20°C
Form:
Liquid
Antigen: Tau
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.: P10636
Gene Symbols: MAPT
Immunogen: KLH conjugated synthetic peptide derived from human Tau.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 12F4
Conjugate: Unconjugated
Gene: MAPT
Gene Alias: AI413597; AW045860; BOS_19251; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; Mapt; MAPTL; MGC138549; microtubule associated protein tau; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Neuronal Marker; Paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; Tau-4; Tau5
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4137
Content And Storage: -20°C
Form: Liquid
Antigen:
Tau
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.:
P10636
Gene Symbols:
MAPT
Immunogen:
KLH conjugated synthetic peptide derived from human Tau.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
12F4
Conjugate:
Unconjugated
Gene:
MAPT
Gene Alias:
AI413597; AW045860; BOS_19251; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; Mapt; MAPTL; MGC138549; microtubule associated protein tau; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Neuronal Marker; Paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; Tau-4; Tau5
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4137
Content And Storage:
-20°C
Form:
Liquid
Antigen: HP1 alpha
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.: P45973
Gene Symbols: Cbx5
Immunogen: KLH conjugated synthetic peptide derived from human HP1 alpha.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: 7000
Conjugate: Unconjugated
Gene: Cbx5
Gene Alias: 2610029O15Rik; Antigen p25; BOS_4984; C75991; CBX5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 23468
Content And Storage: -20°C
Form: Liquid
Antigen:
HP1 alpha
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene Accession No.:
P45973
Gene Symbols:
Cbx5
Immunogen:
KLH conjugated synthetic peptide derived from human HP1 alpha.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
7000
Conjugate:
Unconjugated
Gene:
Cbx5
Gene Alias:
2610029O15Rik; Antigen p25; BOS_4984; C75991; CBX5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
23468
Content And Storage:
-20°C
Form:
Liquid