50-199-0077

Stat4Rabbit anti-Mouse, Polyclonal, Rockland™

Manufacturer: Rockland Immunochemicals

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Each of 1 50-199-0077-Each-of-1 In Stock ₹ 50,884.24

50-199-0077 - Each of 1

₹ 50,884.24

In Stock

Quantity

1

Base Price: ₹ 50,884.24

GST (18%): ₹ 9,159.163

Total Price: ₹ 60,043.403

Antigen

Stat4

Classification

Polyclonal

Conjugate

Unconjugated

Gene

STAT4

Gene Alias

CIS4; HSPC060; OTTHUMP00000163553; Signal transducer and activator of transcription 4; SLEB11; SOCS4; SOCS6; SSI4; STAI4; STAT; STAT4; STATI4

Host Species

Rabbit

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Applications

ELISA, Immunoprecipitation, Western Blot

Concentration

85 mg/mL

Formulation

0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Accession No.

P42228

Gene Symbols

STAT4

Immunogen

This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-Terminal region near amino acids 725-749 of Mouse STAT-4.

Regulatory Status

RUO

Gene ID (Entrez)

20849

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Form

Liquid

Description

  • Store vial at -20°C prior to opening
  • Aliquot contents and freeze at -20°C or below for extended storage
  • Avoid cycles of freezing and thawing
  • Centrifuge product if not completely clear after standing at room temperature
  • This product is stable for several weeks at 4°C as an undiluted liquid
  • Dilute only prior to immediate use
  • Reactivity occurs against mouse STAT4 protein
  • Cross reactivity with closely related STAT family members has not been determined
  • Cross reactivity is expected against human STAT4 protein based on a 95% homology of the amino acid sequence of the immunogen between human and mouse
  • A single amino acid change is reported (from N to K)
  • Cross reactivity is expected against rat STAT4
  • STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins
  • The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%)
  • Functionally, STAT4 is similar to other STAT family members in that it can be tyrosine phosphorylated by Jak1 or Jak2
  • STAT4 forms homodimers and heterodimers with related STAT family members
  • Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS)
  • Serine phosphorylation of STAT is also required for maximal transcriptional activity
  • STAT4 expression is restricted to the thymus, spleen and testis
  • Until recently the cytokine(s) responsible for activation of STAT4 had not been identified
  • STAT4 is now known to be activated by the cytokine interleukin 12 (IL-12)
  • IL-12 is required for the T-cell independent induction of IFN-gamma which is a key step in the initial suppression of bacterial and parasitic infections
  • In addition, IL-12 is required for the development of a Th1 response which is necessary for effective host defense against intracellular pathogens
  • STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells
  • A recent study in mouse has shown that in response to viral infection IFN-a/b activation of STAT4 is required for IFN-g production.

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Rockland Immunochemicals

50-199-0077

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Antigen:
Stat4

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
STAT4

Gene Alias:
CIS4; HSPC060; OTTHUMP00000163553; Signal transducer and activator of transcription 4; SLEB11; SOCS4; SOCS6; SSI4; STAI4; STAT; STAT4; STATI4

Host Species:
Rabbit

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Applications:
ELISA, Immunoprecipitation, Western Blot

Concentration:
85 mg/mL

Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Accession No.:
P42228

Gene Symbols:
STAT4

Immunogen:
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-Terminal region near amino acids 725-749 of Mouse STAT-4.

Regulatory Status:
RUO

Gene ID (Entrez):
20849

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Rockland Immunochemicals

50-199-0078

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Antigen:
PI3-kinase p110 delta

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PIK3CD

Gene Alias:
2410099E07Rik; 2610208K16Rik; APDS; AW545373; catalytic phosphatidylinositol 3-kinase delta; IMD14; p100 delta; p110D; P110DELTA; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; phosphoinositide 3 kinase P110delta; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; PI3K; PI3K delta; PI3Kdelta; PI3K-delta; PI3-kinase p110 subunit delta; PI3-kinase subunit delta; PI3Kp110delta; PI3K-p110delta; Pik3cd; ptdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta

Host Species:
Rabbit

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Applications:
ELISA, Western Blot

Concentration:
85 mg/mL

Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Accession No.:
O00329, O35904

Gene Symbols:
PIK3CD

Immunogen:
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminal of mouse PI3K p110d. This sequence is identical in both mouse and human.

Regulatory Status:
RUO

Gene ID (Entrez):
18707, 5293

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Rockland Immunochemicals

50-199-0079

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Antigen:
GADD45 gamma

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
GADD45G

Gene Alias:
AI327420; C86281; CR6; Cytokine-responsive protein CR6; DDIT2; DDIT-2; DNA damage-inducible transcript 2 protein; GADD45G; GADD45gamma; GADD45-gamma; gadd-related protein, 17 kD; growth arrest and DNA damage inducible; growth arrest and DNA damage inducible gamma; Growth arrest and DNA damage-inducible protein GADD45 gamma; growth arrest and DNA-damage-inducible 45 gamma; growth arrest and DNA-damage-inducible protein GADD45 gamma; growth arrest and DNA-damage-inducible, gamma; GRP17; OIG37; RP11-260L6.1

Host Species:
Rabbit

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Mouse, Rat

Product Type:
Antibody

Applications:
ELISA, Immunoprecipitation, Western Blot

Concentration:
85 mg/mL

Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Accession No.:
Q9WTQ7, Q9Z111

Gene Symbols:
GADD45G

Immunogen:
Synthetic peptide corresponding to amino acids 142-159 of Mouse GADD45 gamma. Swiss Prot accession number Q9Z111. This sequence represents the C-terminal end of the protein. Mouse and rat GADD45 g show 100% sequence homology. A single amino acid change is found in the human sequence.

Regulatory Status:
RUO

Gene ID (Entrez):
23882, 291005

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

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Bioworld

50-199-008

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