Erpd/Arp37 Polyclonal Antibody, Rockland™

Description

• Store vial at 4°C prior to restoration
• For extended storage aliquot contents and freeze at -20°C or below
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• It is directed against, and shows specific reactivity for, Borrelia burgdorferi ErpD protein
• Reactivity with ErpD/Arp37 protein from other sources has not been determined
• Erp proteins from Borrelia burgdorferi are postulated to be lipoproteins, based on their predicted amino acid sequences
• The spirochete migrates from the tick midgut during feeding to its salivary glands and are thus transmitted to the mammal host
• This transition may be facilitated by changes in expression of some B
• burgdorferi genes
• It is believed that expression of the various proteins associated with the spirochete may be regulated by the changes in tick life cycle, changes in conditions during tick feeding (such as temperature, pH, and nutrients) and/or in coordination with the course of infection of the mammal host
• Several studies have demonstrated that infected humans and animals produce antibodies directed against Erp proteins within the first 2-4 weeks of infection, indicative of Erp synthesis during the initial stages of vertebrate infection
• It is postulated that surface-exposed Erp proteins could facilitate interactions with host tissues during the establishment of vertebrate infection.