CRP Polyclonal Antibody, FITC, Rockland™

Description

• Store vial at 4°C prior to restoration
• For extended storage aliquot contents and freeze at -20°C or below
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-fluorescein, anti-Goat Serum, purified and partially purified Human CRP
• CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits
• Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa
• CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body
• CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance
• Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation
• CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages
• CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis
• CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood
• Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.