50-199-1499

IL-1 beta Rabbit anti-Mouse, Rat, Biotin, Polyclonal, Rockland™

Manufacturer: Rockland Immunochemicals

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Pack Size SKU Availability Price
Each of 1 50-199-1499-Each-of-1 In Stock ₹ 48,865.03

50-199-1499 - Each of 1

₹ 48,865.03

In Stock

Quantity

1

Base Price: ₹ 48,865.03

GST (18%): ₹ 8,795.705

Total Price: ₹ 57,660.735

Antigen

IL-1 beta

Classification

Polyclonal

Conjugate

Biotin

Gene

IL1B

Gene Alias

BOS_11619; Catabolin; IL 1ß; IL-1; IL1 B; IL-1 beta; Il1b; Il-1b; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; interleukin 1, beta; Interleukin1 beta; Interleukin-1 beta; interleukin-1 beta proprotein; interleukin-1 beta-like; interleukin-beta; LOC100052414; Lymphocyte proliferation-potentiating factor; preinterleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta

Host Species

Rabbit

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Mouse, Rat

Product Type

Antibody

Applications

ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot

Concentration

1 mg/mL

Formulation

0.02M potassium phosphate with 0.15M NaCl, 10 mg/mL BSA and 0.01% sodium azide; pH 7.2

Gene Accession No.

P10749, Q63264

Gene Symbols

IL1B

Immunogen

This antibody was prepared by repeated immunizations with recombinant mouse IL-1beta produced in E.coli. The MW of recombinant mouse IL-1beta was 17 kDa.

Regulatory Status

RUO

Gene ID (Entrez)

16176, 24494

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Lyophilized

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Description

  • Store vial at 4°C prior to restoration
  • For extended storage aliquot contents and freeze at -20°C or below
  • Avoid cycles of freezing and thawing
  • Centrifuge product if not completely clear after standing at room temperature
  • This product is stable for several weeks at 4°C as an undiluted liquid
  • Dilute only prior to immediate use
  • This antibody was heated to 56°C for 30 minutes
  • This is an IgG preparation of whole rabbit serum purified by DEAE fractionation
  • This antibody is primarily directed against mature, 17,000 MW mouse IL-1 beta and is useful in determining its presence in various assays
  • The antibody does not recognize human IL-1 beta or mouse IL-1 alpha
  • In ELISA formats and other immunoreactive assays, reactivity occurs with rat IL-1 beta
  • This antibody will recognize 10% of the non-denatured (native) precursor 31,000 MW mouse IL-1 beta containing samples but will primarily detect all of the 17,000 MW mature molecule
  • However, in immunoblot analysis, the usual procedure of heating the sample in SDS with or without reducing agents will facilitate denaturing of the 31,000 MW IL- 1 beta precursor molecule
  • Denatured 31,000 precursor IL-1 beta will be recognized by this antibody
  • Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells
  • IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol
  • Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals
  • Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta
  • IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism
  • Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions
  • IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha
  • IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition
  • IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury
  • Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

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Show Difference

Img

Rockland Immunochemicals

50-199-1499

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Antigen:
IL-1 beta

Classification:
Polyclonal

Conjugate:
Biotin

Gene:
IL1B

Gene Alias:
BOS_11619; Catabolin; IL 1ß; IL-1; IL1 B; IL-1 beta; Il1b; Il-1b; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; interleukin 1, beta; Interleukin1 beta; Interleukin-1 beta; interleukin-1 beta proprotein; interleukin-1 beta-like; interleukin-beta; LOC100052414; Lymphocyte proliferation-potentiating factor; preinterleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta

Host Species:
Rabbit

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse, Rat

Product Type:
Antibody

Applications:
ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot

Concentration:
1 mg/mL

Formulation:
0.02M potassium phosphate with 0.15M NaCl, 10 mg/mL BSA and 0.01% sodium azide; pH 7.2

Gene Accession No.:
P10749, Q63264

Gene Symbols:
IL1B

Immunogen:
This antibody was prepared by repeated immunizations with recombinant mouse IL-1beta produced in E.coli. The MW of recombinant mouse IL-1beta was 17 kDa.

Regulatory Status:
RUO

Gene ID (Entrez):
16176, 24494

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Lyophilized

Img

Bioworld

50-199-150

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Antigen:
__

Classification:
__

Conjugate:
__

Gene:
__

Gene Alias:
__

Host Species:
__

Quantity:
__

Primary or Secondary:
__

Target Species:
__

Product Type:
__

Applications:
__

Concentration:
__

Formulation:
__

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
__

Regulatory Status:
__

Gene ID (Entrez):
__

Content And Storage:
__

Form:
__

Img

Rockland Immunochemicals

50-199-1503

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Antigen:
IL-35 EBI3

Classification:
Polyclonal

Conjugate:
Biotin

Gene:
Ebi3

Gene Alias:
cytokine receptor; EBI3; EBI-3; EBV-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus induced gene 3; Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor); Epstein-Barr virus-induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein homolog; Il27; IL-27; IL27 p28; IL-27 p28 subunit; IL27 subunit; IL-27 subunit alpha; IL-27 subunit beta; Il27a; IL-27A; IL-27-A; IL27-A; IL27B; IL-27B; IL27p28; IL-27p28; IL30; IL35 subunit; ILN; Interleukin; interleukin 27; interleukin 30; Interleukin-27 subunit alpha; Interleukin-27 subunit beta; Interleukin-30; MGC71873; M-IL-27 (p28); p28; RGD1561420

Host Species:
Rabbit

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse, Rat

Product Type:
Antibody

Applications:
ELISA, Immunohistochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
0.02M potassium phosphate with 0.15M NaCl, 10 mg/mL BSA and 0.01% sodium azide; pH 7.2

Gene Accession No.:
O35228, Q8K3I6

Gene Symbols:
Ebi3, IL27

Immunogen:
This antibody was prepared by repeated immunizations with recombinant mouse EBI3.

Regulatory Status:
RUO

Gene ID (Entrez):
246779, 365368, 50498, 680609

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Lyophilized

Img

Rockland Immunochemicals

50-199-1504

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Antigen:
NAG-1

Classification:
Polyclonal

Conjugate:
Biotin

Gene:
Gdf15

Gene Alias:
GDF15; GDF-15; growth differentiation factor 15; Growth/differentiation factor 15; macrophage inhibiting cytokine-1; Macrophage inhibitory cytokine 1; MIC1; MIC-1; NAG1; NAG-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; Placental TGF-beta; Prostate differentiation factor; PTGFB; PTGF-beta; Sbf

Host Species:
Rabbit

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Applications:
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot

Concentration:
1 mg/mL

Formulation:
0.02M potassium phosphate with 0.15M NaCl, 10 mg/mL BSA and 0.01% sodium azide; pH 7.2

Gene Accession No.:
Q99988, Q9Z0J7

Gene Symbols:
Gdf15

Immunogen:
This Protein-A purified antibody was prepared by repeated immunizations with an MBP-tagged recombinant protein produced in E.coli corresponding to full-length mouse NAG-1 protein. Cross reactivity to MBP was removed via cross-adsorption chromatography.

Regulatory Status:
RUO

Gene ID (Entrez):
23886, 9518

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Lyophilized