Caspase-2Rabbit anti-Mouse, Rat, Polyclonal, Rockland™

Description

• Store vial at -20°C prior to opening
• Aliquot contents and freeze at -20°C or below for extended storage
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• This affinity purified antibody is directed against rat and mouse caspase-2
• The antibody detects long and short forms of the protein
• This antibody reacts with mouse and rat caspase-2, but not caspase-2 from human sources
• Cross reactivity with caspase-2 from other sources has not been determined
• Rat and mouse caspase-2 show 94% homology
• There is no significant homology to the human form
• Caspase 2 gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family
• Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis
• Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme
• The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli
• Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.