Phospho-Androgen Receptor (Tyr267)Rabbit anti-Human, Polyclonal, Rockland™

Description

• Store vial at -20°C prior to opening
• Aliquot contents and freeze at -20°C or below for extended storage
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• A BLAST analysis was used to suggest cross-reactivity with human and chimpanzee based on 100% sequence homology
• Cross-reactivity with Androgen Receptor pY267 from other sources has not been determined
• The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors
• The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain
• The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT)
• Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes
• The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis
• AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain
• Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase)
• The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor
• Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility
• Mutations in this gene are associated with complete androgen insensitivity (CAIS).