50-199-2746

FOXO1/FKHR Polyclonal Antibody, Active Motif™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-199-2746-Each-of-1 In Stock ₹ 12,834.00

50-199-2746 - Each of 1

₹ 12,834.00

In Stock

Quantity

1

Base Price: ₹ 12,834.00

GST (18%): ₹ 2,310.12

Total Price: ₹ 15,144.12

Antigen

FOXO1/FKHR

Classification

Polyclonal

Conjugate

Unconjugated

Gene

FOXO1

Gene Alias

Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; Foxo1; Foxo1a; foxO1a.1; zgc:153388

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

2308

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Immunoprecipitation, Western Blot

Concentration

Lot-Specific

Formulation

70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8

Gene Accession No.

Q12778

Gene Symbols

FOXO1

Immunogen

This FOXO1/FkHR antibody was raised against a peptide from the C-terminal region of human FOXO1/FkHR.

Quantity

10 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • FOXO1 (FKHR, ForKHead Box 01) is a member in a subfamily of the forkhead homeotic gene family of transcription factors
  • Recent experiments have shown that FOXO1 can act as either a coactivator or a corepressor of nuclear receptor activity that is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein
  • Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma
  • Recent studies link the anti-tumor activity of FOXO1, the process of autophagy and myogenic growth and differentiation
  • FOXO1 is the main target of insulin signaling that regulated the metabolic homeostasis in response to oxidative stress
  • FOXO1 binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'
  • FOXO1 is a regulator of redox balance, osteoblast numbers and controls bone mass
  • Further, FOXO1 orchestrates the endocrine function of the skeleton in regulating glucose metabolism, and suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP
  • In hepatocytes, FOXO1 promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1
  • FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1.

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Img

Fischer Scientific

50-199-2746

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Antigen:
FOXO1/FKHR

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
FOXO1

Gene Alias:
Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; Foxo1; Foxo1a; foxO1a.1; zgc:153388

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
2308

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunoprecipitation, Western Blot

Concentration:
Lot-Specific

Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8

Gene Accession No.:
Q12778

Gene Symbols:
FOXO1

Immunogen:
This FOXO1/FkHR antibody was raised against a peptide from the C-terminal region of human FOXO1/FkHR.

Quantity:
10 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Fischer Scientific

50-199-2747

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Antigen:
Phospho-SMC1 (Ser957)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SMC1B

Gene Alias:
14S cohesin SMC1 subunit; 5830426I24Rik; BOS_26006; BOS_6225; CDLS2; Chromosome segregation protein SmcB; DKFZp686L19178; DXhXs423e; DXS423E; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mKIAA0178; RP6-29D12.1; SB1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; segregation of mitotic chromosomes-like 1; SM1A; SMC; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein; SMC protein 1A; SMC protein 1B; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 protein cohesin subunit; SMC1 structural maintenance of chromosomes 1-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Smc1a; SMC-1A; smc1a.L; smc1aa; SMC1alpha; SMC-1-alpha; SMC1alpha protein; Smc1b; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L1; SMC1L2; Smcb; SMC-like 1; SMC-protein; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1; structural maintenance of chromosomes 1 like 1; structural maintenance of chromosomes 1A; structural maintenance of chromosomes 1A a; structural maintenance of chromosomes 1A L homeolog; structural maintenance of chromosomes 1B; Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B; XELAEV_18000030mg; xsmc1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
27127, 8243

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Dot Blot, Western Blot

Concentration:
Lot-Specific

Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8

Gene Accession No.:
Q14683, Q8NDV3

Gene Symbols:
SMC1A, SMC1B

Immunogen:
This SMC1 phospho Ser957 antibody was raised against a peptide containing phospho-serine 957 of human SMC1.

Quantity:
200 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Fischer Scientific

50-199-2748

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Antigen:
Phospho-SMC1 (Ser957)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SMC1B

Gene Alias:
14S cohesin SMC1 subunit; 5830426I24Rik; BOS_26006; BOS_6225; CDLS2; Chromosome segregation protein SmcB; DKFZp686L19178; DXhXs423e; DXS423E; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mKIAA0178; RP6-29D12.1; SB1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; segregation of mitotic chromosomes-like 1; SM1A; SMC; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein; SMC protein 1A; SMC protein 1B; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 protein cohesin subunit; SMC1 structural maintenance of chromosomes 1-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Smc1a; SMC-1A; smc1a.L; smc1aa; SMC1alpha; SMC-1-alpha; SMC1alpha protein; Smc1b; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L1; SMC1L2; Smcb; SMC-like 1; SMC-protein; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1; structural maintenance of chromosomes 1 like 1; structural maintenance of chromosomes 1A; structural maintenance of chromosomes 1A a; structural maintenance of chromosomes 1A L homeolog; structural maintenance of chromosomes 1B; Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B; XELAEV_18000030mg; xsmc1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
27127, 8243

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Dot Blot, Western Blot

Concentration:
Lot-Specific

Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8

Gene Accession No.:
Q14683, Q8NDV3

Gene Symbols:
SMC1A, SMC1B

Immunogen:
This SMC1 phospho Ser957 antibody was raised against a peptide containing phospho-serine 957 of human SMC1.

Quantity:
10 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Fischer Scientific

50-199-2749

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Antigen:
Histone H3.3S31ph

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
H3-3A

Gene Alias:
BOS_15646; CG5825; CG5825 gene product from transcript CG5825-RA; CG5825-PA; CG5825-PC; CG5825-PD; CG8989; dH3.3A; Dmel\CG5825; Dmel_CG5825; H3 histone, family 3A; H3.3; H3.3A; H3.3B; H3.4; H3.A; H3.B; H3/g; H3-3A; H3-3B; H3B; H3F3; H3F3A; H3F3B; H3FT; H3L-like histone; H3t; His3.3; His3.3A; His-3.3A; His3.3A-PA; His3.3A-PC; His3.3A-PD; His3.3B; Histone cluster 3; Histone H3; Histone H3.3; histone H3.3 variant; Histone H3.3A; Histone H3.3B; histone H3.3-like; histone variant 3.3; histone variant H3.3; LOC100054462; MGC126886; MGC126888; PH3; PP781

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3020

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Dot Blot, Western Blot

Concentration:
Lot-Specific

Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8

Gene Accession No.:
P84243

Gene Symbols:
H3-3A

Immunogen:
This Histone H3.3 phospho Ser31 antibody was raised against a peptide containing phospho Ser31 of Histone H3.3.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG