50-199-4086

HIF-1 alpha Polyclonal Antibody, Active Motif™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-199-4086-Each-of-1 In Stock ₹ 12,834.00

50-199-4086 - Each of 1

₹ 12,834.00

In Stock

Quantity

1

Base Price: ₹ 12,834.00

GST (18%): ₹ 2,310.12

Total Price: ₹ 15,144.12

Antigen

HIF-1 alpha

Classification

Polyclonal

Conjugate

Unconjugated

Gene

HIF1A

Gene Alias

AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; BOS_11009; Class E basic helix-loop-helix protein 78; HIF1; HIF1 alpha; HIF-1 alpha; hif1a; HIF-1A; hif1a.L; HIF1alpha; hif-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; Member of PAS

Host Species

Rabbit

Quantity

10 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Applications

ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot

Concentration

Conc. Not Determined

Formulation

whole serum with 30% glycerol and 0.035% sodium azide; pH

Gene Accession No.

Q16665

Gene Symbols

HIF1A

Immunogen

This HIF-1 alpha antibody was raised against a synthetic peptide corresponding to the C-terminal region of human HIF-1 alpha.

Regulatory Status

RUO

Gene ID (Entrez)

3091

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Form

Liquid

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Description

  • HIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension
  • HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors
  • HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia
  • Under hypoxic conditions, HIF-1 activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia
  • HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
  • Hypoxia which induces p53 protein accumulation, directly interacts with HIF1-alpha and reduces hypoxia-induced expression of HIF1-alpha by promoting MDM2-mediated ubiquitination and proteasomal degradation under hypoxic conditions
  • Recent studies suggest that induction of NOX4 by HIF1-alpha contributes to maintain ROS levels after hypoxia and hypoxia-induced proliferation
  • In humans, it is located on the q arm of chromosome 14
  • The C-terminal of HIF1A binds to p300
  • p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF
  • Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.

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Img

Fischer Scientific

50-199-4086

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Antigen:
HIF-1 alpha

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
HIF1A

Gene Alias:
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; BOS_11009; Class E basic helix-loop-helix protein 78; HIF1; HIF1 alpha; HIF-1 alpha; hif1a; HIF-1A; hif1a.L; HIF1alpha; hif-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; Member of PAS

Host Species:
Rabbit

Quantity:
10 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot

Concentration:
Conc. Not Determined

Formulation:
whole serum with 30% glycerol and 0.035% sodium azide; pH

Gene Accession No.:
Q16665

Gene Symbols:
HIF1A

Immunogen:
This HIF-1 alpha antibody was raised against a synthetic peptide corresponding to the C-terminal region of human HIF-1 alpha.

Regulatory Status:
RUO

Gene ID (Entrez):
3091

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Fischer Scientific

50-199-4087

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Antigen:
Histone H3K18me1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
H3-3A

Gene Alias:
H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3C; H3 K18; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3.3A; H3.3b; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-143; H3-291; H3-3A; H3-3B; H3-53; H3-614; H3a; H3b; H3-B; H3C1; H3c10; H3c11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3c8; H3f; H3-F; H3F1K; H3F2; H3F3; H3F3A; H3f3b; H3F3C; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3g; H3h; H3i; H3K18; H3K18me; H3Lys18me; H3Lys18me1; Hist1; HIST1H3A; HIST1H3B; Hist1h3c; HIST1H3D; Hist1h3e; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST2H3A; Hist2h3b; HIST2H3C; Hist2h3c1; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1; Hist2h3ca2; HIST2H3D; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3a; histone 2, H3c; histone 2, H3c2; histone 2, H3ca2; Histone 3; histone cluster 1, H3a; histone cluster 1, H3b; histone cluster 1, H3f; histone cluster 1, H3h; histone cluster 2, H3a; histone cluster 2, H3c; histone cluster 2, H3c2; histone cluster 2, H3c2, pseudogene; histone gene complex 1; histone H3; Histone H3.1; Histone H3.2; Histone H3.3; Histone H3.3C; Histone H3.5; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; Histone H3/m; Histone H3/o; Histone H3K18me1; histone variant H3.5; M32461; methyl Histone 3; methyl Histone H3; Methyl-H3 K18; Methyl-H3 Lys18; Methyl-Histone H3 K18; Methyl-Histone H3 Lys18; Mono-methyl H3; Mono-methyl Histone H3; Mono-Methyl-Histone H3 K18; Mono-Methyl-Histone H3 Lys18; PP781

Host Species:
Rabbit

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
Dot Blot, Western Blot

Concentration:
Conc. Not Determined

Formulation:
whole serum with 30% glycerol and 0.035% sodium azide; pH

Gene Accession No.:
P68431, P84243, Q6NXT2, Q71DI3

Gene Symbols:
H3-3A, H3-3B, H3-5, H3C1, H3C10, H3C14, H3C15, H3C2, H3C7

Immunogen:
This Histone H3 monomethyl Lys18 antibody was raised against a peptide containing monomethyl Lys18 of Histone H3.

Regulatory Status:
RUO

Gene ID (Entrez):
126961, 3020, 3021, 333932, 440093, 8350, 8357, 8358, 8968

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Fischer Scientific

50-199-4088

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Antigen:
Histone H3K18me1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
H3-3A

Gene Alias:
H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3C; H3 K18; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3.3A; H3.3b; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-143; H3-291; H3-3A; H3-3B; H3-53; H3-614; H3a; H3b; H3-B; H3C1; H3c10; H3c11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3c8; H3f; H3-F; H3F1K; H3F2; H3F3; H3F3A; H3f3b; H3F3C; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3g; H3h; H3i; H3K18; H3K18me; H3Lys18me; H3Lys18me1; Hist1; HIST1H3A; HIST1H3B; Hist1h3c; HIST1H3D; Hist1h3e; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST2H3A; Hist2h3b; HIST2H3C; Hist2h3c1; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1; Hist2h3ca2; HIST2H3D; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3a; histone 2, H3c; histone 2, H3c2; histone 2, H3ca2; Histone 3; histone cluster 1, H3a; histone cluster 1, H3b; histone cluster 1, H3f; histone cluster 1, H3h; histone cluster 2, H3a; histone cluster 2, H3c; histone cluster 2, H3c2; histone cluster 2, H3c2, pseudogene; histone gene complex 1; histone H3; Histone H3.1; Histone H3.2; Histone H3.3; Histone H3.3C; Histone H3.5; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; Histone H3/m; Histone H3/o; Histone H3K18me1; histone variant H3.5; M32461; methyl Histone 3; methyl Histone H3; Methyl-H3 K18; Methyl-H3 Lys18; Methyl-Histone H3 K18; Methyl-Histone H3 Lys18; Mono-methyl H3; Mono-methyl Histone H3; Mono-Methyl-Histone H3 K18; Mono-Methyl-Histone H3 Lys18; PP781

Host Species:
Rabbit

Quantity:
10 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
Dot Blot, Western Blot

Concentration:
Conc. Not Determined

Formulation:
whole serum with 30% glycerol and 0.035% sodium azide; pH

Gene Accession No.:
P68431, P84243, Q6NXT2, Q71DI3

Gene Symbols:
H3-3A, H3-3B, H3-5, H3C1, H3C10, H3C14, H3C15, H3C2, H3C7

Immunogen:
This Histone H3 monomethyl Lys18 antibody was raised against a peptide containing monomethyl Lys18 of Histone H3.

Regulatory Status:
RUO

Gene ID (Entrez):
126961, 3020, 3021, 333932, 440093, 8350, 8357, 8358, 8968

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Fischer Scientific

50-199-4093

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Antigen:
Phospho-NFkB p65 (Ser536)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
RELA

Gene Alias:
avian reticuloendotheliosis viral (v-rel) oncogene homolog A; BOS_24973; EBP-1; I79_021812; MGC131774; NFkappaB p65; NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NF-kappaB transcription factor p65 subunit; NFkB; NFKB1; Nfkb3; NFkB-p50; nuclear factor kappa B subunit p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; p65; p65 NF kappaB; p65 NF-kappa B; p65 NFkB; P65 transcription factor; Putative transcription factor p65 homolog; rel1; Rela; RELA proto-oncogene, NF-kB subunit; rela.L; rela-a; Transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel avian reticuloendotheliosis viral oncogene homolog A L homeolog; v-rel reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65; XELAEV_18022301mg; XRel1; xrela

Host Species:
Rabbit

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
Dot Blot, Western Blot

Concentration:
Conc. Not Determined

Formulation:
whole serum with 30% glycerol and 0.035% sodium azide; pH

Gene Accession No.:
Q04206

Gene Symbols:
RELA

Immunogen:
This NFkB p65 phospho Ser536 antibody was raised against a peptide containing phospho-serine 536 of human NFkB p65.

Regulatory Status:
RUO

Gene ID (Entrez):
5970

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid