50-209-0138
SAV1 Recombinant Rabbit Monoclonal Antibody (2H8L41), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-209-0138-Each | In Stock | ₹ 39,841.01 |
50-209-0138 - Each
In Stock
Quantity
1
Base Price: ₹ 39,841.01
GST (18%): ₹ 7,171.382
Total Price: ₹ 47,012.392
Antigen
SAV1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
Q8VEB2, Q9H4B6
Gene Symbols
SAV1
Immunogen
Protein corresponding to human SAV1 [aa300-aa383]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
2H8L41
Conjugate
Unconjugated
Gene
SAV1
Gene Alias
1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
60485, 64010
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Rat, Bovine
- Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues
- It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250
- In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
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Antigen: SAV1
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.: Q8VEB2, Q9H4B6
Gene Symbols: SAV1
Immunogen: Protein corresponding to human SAV1 [aa300-aa383]
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: 2H8L41
Conjugate: Unconjugated
Gene: SAV1
Gene Alias: 1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 60485, 64010
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
SAV1
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.:
Q8VEB2, Q9H4B6
Gene Symbols:
SAV1
Immunogen:
Protein corresponding to human SAV1 [aa300-aa383]
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
2H8L41
Conjugate:
Unconjugated
Gene:
SAV1
Gene Alias:
1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
60485, 64010
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
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