DLK1 Rabbit, anti-Human, Unconjugated, Polyclonal, Proteintech

Description

• DLK1, also named PREF1, FA1, or pG2, is a transmembrane protein belonging to the epidermal growth factor (EGF)-like superfamily (PMID: 8095043)
• It contains six EGF-like repeats in the extracellular region
• DLK1 is abundant in preadipocytes and regulate adipocyte differentiation negatively (PMID: 8500166)
• Deficiency of DLK1 gives rise to growth retardation and accelerated adiposity in mouse model
• Expression of DLK1 is found in tumors with neuroendocrine features that implies DLK1 may be involved in neuroendocrine differentiation (PMID: 8095043)
• It has been reported overexpression of DLK1 could lead to the development of metabolic abnormalities by impairment of adipocyte function in mice (PMID: 12588883)
• The gene of DLK1 maps to chromosome 14q32, and encodes a 383-amino acid protein with a calculated molecular mass of 41 kDa
• In preadipocytes, multiple discrete forms of DLK1 protein of 45-60 kDa are present, owing in part to N-linked glycosylation (PMID: 8500166).