50-223-8976
CD279 Mouse anti-Human, Unconjugated, Clone: EH12.2H7, Proteintech
Manufacturer: Proteintech Group Inc
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-223-8976-Each-of-1 | In Stock | ₹ 4,962.48 |
50-223-8976 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 4,962.48
GST (18%): ₹ 893.246
Total Price: ₹ 5,855.726
Antigen
CD279
Classification
Monoclonal
Concentration
1 mg/mL
Host Species
Mouse
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
EH12.2H7
Conjugate
Unconjugated
Quantity
100 μg
Gene ID (Entrez)
5133
Form
Liquid
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Description
- Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily
- It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375)
- PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820)
- Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218)
- It is critical for the regulation of T cell function during immunity and tolerance
- Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436).
Compare Similar Items
Show Difference
Antigen: CD279
Classification: Monoclonal
Concentration: 1 mg/mL
Host Species: Mouse
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: EH12.2H7
Conjugate: Unconjugated
Quantity: 100 μg
Gene ID (Entrez): 5133
Form: Liquid
Antigen:
CD279
Classification:
Monoclonal
Concentration:
1 mg/mL
Host Species:
Mouse
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
EH12.2H7
Conjugate:
Unconjugated
Quantity:
100 μg
Gene ID (Entrez):
5133
Form:
Liquid
Antigen: CD83
Classification: Monoclonal
Concentration: 1 mg/mL
Host Species: Mouse
Primary or Secondary: Primary
Target Species: Human, Non-human Primate
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: HB15e
Conjugate: Unconjugated
Quantity: 100 μg
Gene ID (Entrez): 9308
Form: Liquid
Antigen:
CD83
Classification:
Monoclonal
Concentration:
1 mg/mL
Host Species:
Mouse
Primary or Secondary:
Primary
Target Species:
Human, Non-human Primate
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
HB15e
Conjugate:
Unconjugated
Quantity:
100 μg
Gene ID (Entrez):
9308
Form:
Liquid
Antigen: CD5
Classification: Monoclonal
Concentration: 500 μg/mL
Host Species: Mouse
Primary or Secondary: Primary
Target Species: Human
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: L17F12
Conjugate: Unconjugated
Quantity: 100 μg
Gene ID (Entrez): 921
Form: Liquid
Antigen:
CD5
Classification:
Monoclonal
Concentration:
500 μg/mL
Host Species:
Mouse
Primary or Secondary:
Primary
Target Species:
Human
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
L17F12
Conjugate:
Unconjugated
Quantity:
100 μg
Gene ID (Entrez):
921
Form:
Liquid
Antigen: CD7
Classification: Monoclonal
Concentration: 500 μg/mL
Host Species: Mouse
Primary or Secondary: Primary
Target Species: Human
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: 4H9
Conjugate: Unconjugated
Quantity: 100 μg
Gene ID (Entrez): 924
Form: Liquid
Antigen:
CD7
Classification:
Monoclonal
Concentration:
500 μg/mL
Host Species:
Mouse
Primary or Secondary:
Primary
Target Species:
Human
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
4H9
Conjugate:
Unconjugated
Quantity:
100 μg
Gene ID (Entrez):
924
Form:
Liquid