MLH1 Mouse, anti-Human, Unconjugated, Clone: 2F12C4, Proteintech

Description

• MLH1, also named as COCA2, belongs to the DNA mismatch repair mutL/hexB family
• It heterodimerizes with PMS2 to form MutL alpha which is a component of the post-replicative DNA mismatch repair system (MMR)
• MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR
• MLH1 also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages
• MLH1 heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.(PMID: 16873062, PMID: 18206974) Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2)
• Defects in MLH1 are a cause of mismatch repair cancer syndrome (MMRCS)
• Defects in MLH1 are a cause of Muir-Torre syndrome (MTS)
• Defects in MLH1 are a cause of susceptibility to endometrial cancer
• Western blot analysis with an MLH1 antibody detected a 85-100 kDa band
• Full-length human MLH1 is specifically cleaved into degradation products of 40-45 kDa by caspase-3 (PMID: 15087450, PMID: 19603033)
• This antibody is specific to MLH1.