CREST Rabbit anti-Human, CoraLite 488, Polyclonal, Proteintech

Description

• CREST, also named as SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons
• It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain
• It helps regulate neuronal morphogenesis in calcuim-dependent manner
• The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation
• It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex
• This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP
• The calculated molecular weight of CREST is about 43 kDa, but the modified of CREST protein is 55 kDa (PMID: 25888396)
• CREST exists some isoforms with calulated MV 43, 40, 33 and 29 kDa.