VEGF Rabbit anti-Human, CoraLite 488, Polyclonal, Proteintech

Description

• VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family
• It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth
• VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels
• It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin
• Defects in VEGFA are associated with microvascular complications of diabetes type 1 (MVCD1)
• VEGFA has 17 isoforms with MW from 16 to 45 kDa
• Some isoforms have homodimer forms (e.g.; VEGFA189 38kDa or VEFGA110 34kDa)
• VEGF-A exists in at least seven homodimeric isoforms
• The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids (PMID:15602010 )
• This antibody can recognize all VEGFA isoforms.