CD131 Monoclonal Antibody (1C1), PE, eBioscience™, Invitrogen™

Description

• Description: The 1C1 monoclonal antibody reacts with the human CD131 molecule, also known as the common beta subunit (betaC)
• The common beta subunit associates with the specific alpha subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines
• These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response
• Applications Reported: This 1C1 antibody has been reported for use in flow cytometric analysis
• Applications Tested: This 1C1 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
• This can be used at 5 μL (0.25 μg) per test
• A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
• Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
• Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
• Filtration: 0.2 μm post-manufacturing filtered
• The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF
• Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP).