50-255-0887
CD47 Monoclonal Antibody (2D3), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-255-0887-Each-of-1 | In Stock | ₹ 2,96,893.20 |
50-255-0887 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 2,96,893.20
GST (18%): ₹ 53,440.776
Total Price: ₹ 3,50,333.976
Antigen
CD47
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q08722
Gene Symbols
CD47
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
961
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Western Blot
Clone
2D3
Conjugate
Unconjugated
Gene
CD47
Gene Alias
9130415E20Rik; AA407862; AI848868; antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; AW108519; B430305P08Rik; Cd47; CD47 antigen; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 antigen/integrin-associated protein; CD47 glycoprotein; CD47 molecule; CD47/IAP; IAP; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; Itgp; Leukocyte surface antigen CD47; MER6; OA3; Protein MER6; Rh-related antigen; sCD47; soluble CD 47; soluble CD47
Host Species
Mouse
Quantity
10 mg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Description
- The MAb 2D3 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin
- CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain
- CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with beta3 integrins CD51/CD61 and CD41/CD61
- Furthermore this interaction can mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages
- CD47 is the receptor for thrombospondin
- T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin)
- Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex)
- Expression is also found in non-hematopoietic cells
- CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions
- Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins
- Functionally, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix
- CD47 is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction
- CD47 has broad tissue distribution, is reduced in expression on Rh erythrocytes
- CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells
- Moreover, CD47-CD172a system affects cell migration, B cell adhesion, T cell activation, and is involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
Compare Similar Items
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Antigen: CD47
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q08722
Gene Symbols: CD47
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 961
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Western Blot
Clone: 2D3
Conjugate: Unconjugated
Gene: CD47
Gene Alias: 9130415E20Rik; AA407862; AI848868; antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; AW108519; B430305P08Rik; Cd47; CD47 antigen; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 antigen/integrin-associated protein; CD47 glycoprotein; CD47 molecule; CD47/IAP; IAP; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; Itgp; Leukocyte surface antigen CD47; MER6; OA3; Protein MER6; Rh-related antigen; sCD47; soluble CD 47; soluble CD47
Host Species: Mouse
Quantity: 10 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD47
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q08722
Gene Symbols:
CD47
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
961
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Western Blot
Clone:
2D3
Conjugate:
Unconjugated
Gene:
CD47
Gene Alias:
9130415E20Rik; AA407862; AI848868; antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; AW108519; B430305P08Rik; Cd47; CD47 antigen; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 antigen/integrin-associated protein; CD47 glycoprotein; CD47 molecule; CD47/IAP; IAP; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; Itgp; Leukocyte surface antigen CD47; MER6; OA3; Protein MER6; Rh-related antigen; sCD47; soluble CD 47; soluble CD47
Host Species:
Mouse
Quantity:
10 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: ErbB4 (Her4)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: Q15303, Q61527
Gene Symbols: ERBB4
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13869, 2066
Content And Storage: 4°, C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: HFR1
Conjugate: Biotin
Gene: ERBB4
Gene Alias: 4ICD, ALS19, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, avian erythroblastosis oncogene B 4, c-erbB-4, erb-b2 receptor tyrosine kinase 4, Erbb4, ERBB4 intracellular domain, ERBB4 transcript variant I12DEL, ERBB4 transcript variant I20DEL, Her4, human epidermal growth factor receptor 4, Mer4, OTTHUMP00000209432, p180erbB4, proto-oncogene-like protein c-ErbB-4, receptor tyrosine kinase, receptor tyrosine-protein kinase erbB-4, s80HER4, Tyro-2, Tyrosine kinase-type cell surface receptor HER4, v-erb-a erythroblastic leukemia viral oncogene homolog 4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), v-erb-b2 avian erythroblastic leukemia viral oncogene 4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: __
Isotype: IgG2b κ
Antigen:
ErbB4 (Her4)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
Q15303, Q61527
Gene Symbols:
ERBB4
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13869, 2066
Content And Storage:
4°, C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
HFR1
Conjugate:
Biotin
Gene:
ERBB4
Gene Alias:
4ICD, ALS19, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, avian erythroblastosis oncogene B 4, c-erbB-4, erb-b2 receptor tyrosine kinase 4, Erbb4, ERBB4 intracellular domain, ERBB4 transcript variant I12DEL, ERBB4 transcript variant I20DEL, Her4, human epidermal growth factor receptor 4, Mer4, OTTHUMP00000209432, p180erbB4, proto-oncogene-like protein c-ErbB-4, receptor tyrosine kinase, receptor tyrosine-protein kinase erbB-4, s80HER4, Tyro-2, Tyrosine kinase-type cell surface receptor HER4, v-erb-a erythroblastic leukemia viral oncogene homolog 4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), v-erb-b2 avian erythroblastic leukemia viral oncogene 4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
__
Isotype:
IgG2b κ
Antigen: CD68
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: P34810
Gene Symbols: Cd68
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 968
Content And Storage: 4°, C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 815CU17
Conjugate: Biotin
Gene: Cd68
Gene Alias: CD68, CD68 antigen, CD68 molecule, GP110, Lamp4, macrophage antigen CD68, macrosialin, Scard1, scavenger receptor class D, member 1, similar to CD68 antigen
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: __
Isotype: IgG1 κ
Antigen:
CD68
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
P34810
Gene Symbols:
Cd68
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
968
Content And Storage:
4°, C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
815CU17
Conjugate:
Biotin
Gene:
Cd68
Gene Alias:
CD68, CD68 antigen, CD68 molecule, GP110, Lamp4, macrophage antigen CD68, macrosialin, Scard1, scavenger receptor class D, member 1, similar to CD68 antigen
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
__
Isotype:
IgG1 κ
Antigen: CD185 (CXCR5)
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: 0
Gene Symbols: CXCR5
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 701792
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: 87.1
Conjugate: PE
Gene: CXCR5
Gene Alias: Blr1; Blr-1; Burkitt lymphoma receptor 1; burkitt lymphoma receptor 1 homolog; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD185; CD185 antigen; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; CXC; C-X-C chemokine receptor type 5; CXC motif chemokine; C-X-C motif chemokine receptor 5; CXCR5; CXC-R5; CXCR-5; EGK_06966; Fusin; Gpcr6; GPR9; HUMSTR; LESTR; MDR15; MDR-15; Monocyte-derived receptor 15; neurolymphatic receptor; NLR
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Non-human Primate, Rhesus Monkey
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD185 (CXCR5)
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
0
Gene Symbols:
CXCR5
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
701792
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
87.1
Conjugate:
PE
Gene:
CXCR5
Gene Alias:
Blr1; Blr-1; Burkitt lymphoma receptor 1; burkitt lymphoma receptor 1 homolog; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD185; CD185 antigen; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; CXC; C-X-C chemokine receptor type 5; CXC motif chemokine; C-X-C motif chemokine receptor 5; CXCR5; CXC-R5; CXCR-5; EGK_06966; Fusin; Gpcr6; GPR9; HUMSTR; LESTR; MDR15; MDR-15; Monocyte-derived receptor 15; neurolymphatic receptor; NLR
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Non-human Primate, Rhesus Monkey
Product Type:
Antibody
Isotype:
IgG1 κ