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50-901-582

Phospho-BTK/ITK (Tyr551, Tyr511) Monoclonal Antibody (M4G3LN), eFluor™ 660, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Pack Size	SKU	Availability	Price
Each of 1	50-901-582-Each-of-1	In Stock	₹ 38,416.44

50-901-582 - Each of 1

₹ 38,416.44

In Stock

Quantity

Base Price: ₹ 38,416.44

GST (18%): ₹ 6,914.959

Total Price: ₹ 45,331.399

Antigen

Phospho-BTK/ITK (Tyr551, Tyr511)

Classification

Monoclonal

Concentration

0.2 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P35991, Q03526, Q06187, Q08881

Gene Symbols

BTK, ITK

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

12229, 16428, 3702, 695

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin)

Clone

M4G3LN

Conjugate

eFluor 660

Gene

ITK

Gene Alias

agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; Emt; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; IMD1; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMB; kinase EMT; Kinase TLK; LPFS1; LYK; PSCTK1; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; truncated Bruton agammaglobulinemia tyrosine kinase; Tsk; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk; xid; XLA; X-linked immune deficiency

Host Species

Mouse

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG2b κ

Related Products

Description

This M4G3LN MAb recognizes human and mouse Bruton's tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively
In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family
The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk
Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering
BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180
Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively
People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency
Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting
In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family
The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk
Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering
BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180
Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively
People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.

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Invitrogen

50-901-582

Antigen:

Phospho-BTK/ITK (Tyr551, Tyr511)

Classification:

Monoclonal

Concentration:

0.2 mg/mL

Formulation:

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.:

P35991, Q03526, Q06187, Q08881

Gene Symbols:

BTK, ITK

Purification Method:

Affinity chromatography

Regulatory Status:

RUO

Gene ID (Entrez):

12229, 16428, 3702, 695

Content And Storage:

4° C, store in dark, DO NOT FREEZE!

Form:

Liquid

Applications:

Immunocytochemistry, Immunohistochemistry (Paraffin)

Clone:

M4G3LN

Conjugate:

eFluor 660

Gene:

ITK

Gene Alias:

agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; Emt; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; IMD1; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMB; kinase EMT; Kinase TLK; LPFS1; LYK; PSCTK1; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; truncated Bruton agammaglobulinemia tyrosine kinase; Tsk; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk; xid; XLA; X-linked immune deficiency

Host Species:

Mouse

Quantity:

100 μg

Primary or Secondary:

Primary

Target Species:

Human, Mouse

Product Type:

Antibody

Isotype:

IgG2b κ

Teledyne ISCO, Inc

50-901-8217

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Teledyne ISCO, Inc

50-901-8220

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Teledyne ISCO, Inc

50-901-8221

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Phospho-BTK/ITK (Tyr551, Tyr511) Monoclonal Antibody (M4G3LN), eFluor™ 660, eBioscience™, Invitrogen™

Select a Size

Select a Size

Properties

Antigen

Classification

Concentration

Formulation

Gene Accession No.

Gene Symbols

Purification Method

Regulatory Status

Gene ID (Entrez)

Content And Storage

Form

Applications

Clone

Conjugate

Gene

Gene Alias

Host Species

Quantity

Primary or Secondary

Target Species

Product Type

Isotype

Related Products

Invitrogen

Invitrogen

Invitrogen

Invitrogen

Invitrogen

Invitrogen

Invitrogen

Invitrogen

Description

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Invitrogen

Teledyne ISCO, Inc

Teledyne ISCO, Inc

Teledyne ISCO, Inc