CD56 Mouse anti-Human, APC-R700, Clone: NCAM16.2, BD

Description

• The NCAM16.2 monoclonal antibody specifically binds to human CD56
• It recognizes an extracellular immunoglobulin-like domain common to 120, 140, and 180 kDa forms of CD56, also known as the neural cell adhesion molecule (NCAM), NKH1 or MSK39
• The CD56 antigen is expressed on approximately 10% to 25% of peripheral blood lymphocytes
• It is present on essentially all resting and activated CD16+ natural killer (NK) lymphocytes and approximately 5% of CD3+ peripheral blood lymphocytes
• CD3+ CD56+ T lymphocytes comprise a unique subset of cytotoxic T lymphocytes that mediates non-major histocompatibility complex (MHC)-restricted cytotoxicity
• CD56 antigen density on NK lymphocytes increases upon cellular activation
• The CD56 antigen is involved in neuronal homotypic cell adhesion and cell differentiation during embryogenesis
• CD16+ CD56+ NK cells demonstrate reciprocal transfer of an activation state with dendritic cells
• This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700
• APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness
• This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).