Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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beta 2-Microglobulin
0.2mg/mL
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Unconjugated
Mouse
Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin
B2M
IgG1 κ
Protein A or G purified
beta 2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta 2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
B2M/1118
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Monoclonal
Purified
RUO
Human, Primate
P61769
567
Full length recombinant human B2M protein
Primary
Store at 4C.
12 kDa