Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Mucin 5AC
0.2 mg/mL
Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence
Unconjugated
Mouse
Extracellular Matrix
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
4586
M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient.
Primary
Store at 4C.
1-13M1
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml, Immunofluorescence 1 - 2 ug/ml
Monoclonal
Purified
RUO
Human, Mouse, Rat, Chicken, Feline, Monkey, Rabbit, Porcine (Negative)
gastric mucin, leB, lewis B blood group antigen, major airway glycoprotein, MUC5, mucin 5, subtypes A and C, tracheobronchial/gastric, mucin 5AC, oligomeric mucus/gel-forming, mucin 5AC, oligomeric mucus/gel-forming pseudogene, mucin-5 subtype AC, tracheobronchial, mucin-5AC, TBM, tracheobronchial mucin
MUC5AC
IgG1 κ
Protein A or G purified
This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC).Its epitope is located in the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. MAb 1-13M1 pairs with MAb 9-13M1 to measure MUC5AC protein by ELISA. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.