62-998-582
CD279 (PD-1) Monoclonal Antibody (J43), Super Bright™ 436, eBioscience™, Invitrogen™
Manufacturer: eBioscience
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 62-998-582-Each-of-1 | In Stock | ₹ 31,058.28 |
62-998-582 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,058.28
GST (18%): ₹ 5,590.49
Total Price: ₹ 36,648.77
Antigen
CD279 (PD-1)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q02242
Gene Symbols
Pdcd1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18566
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
J43
Conjugate
Super Bright 436
Gene
Pdcd1
Gene Alias
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species
Armenian Hamster
Quantity
100μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Description: The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily
- PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice
- PD-1 is expressed mainly on activated T and B lymphocytes
- Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC)
- Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells
- It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells
- When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells
- Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2
- Applications Reported: This J43 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This J43 antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes
- This may be used at less than or equal to 1.0 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC)
- T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC
- PD-1 can bind two different but related ligands, PDL-1 and PDL-2
- Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "edanger signals"e such as LPS or other molecules associated with bacteria or other pathogens
- Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases
- Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Compare Similar Items
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Antigen: CD279 (PD-1)
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: Q02242
Gene Symbols: Pdcd1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18566
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: J43
Conjugate: Super Bright 436
Gene: Pdcd1
Gene Alias: CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species: Armenian Hamster
Quantity: 100μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
CD279 (PD-1)
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q02242
Gene Symbols:
Pdcd1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18566
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
J43
Conjugate:
Super Bright 436
Gene:
Pdcd1
Gene Alias:
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species:
Armenian Hamster
Quantity:
100μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Lambda light chain
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.: P01701, P0CG04
Gene Symbols: IGL, IGLC1, IGLV, IGLV1-51
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 28820, 3535, 3537, 3546
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: 1-155-2
Conjugate: Super Bright 436
Gene: IGLV1-51
Gene Alias: Bence Jones Protein, BJP, Clambda1, Ig lambda chain V-I region BL2, IgL, Igl@, IGLC, IGLC 1/2/3, IGLC1, Igl-C1, IGLL5, IGLV, IGLV@, immmunoglobulin lambda light chain variable region, Immunoglobulin L, immunoglobulin lambda chain complex, immunoglobulin lambda constant 1, immunoglobulin lambda constant 7, immunoglobulin lambda light chain, immunoglobulin lambda light chain constant region, immunoglobulin lambda light chain V-J region, immunoglobulin lambda variable cluster, Lambda LC, lambda-immunoglobulin, LOC100060608, Mcg Marker, Paraprotein
Host Species: Mouse
Quantity: 25 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Lambda light chain
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.:
P01701, P0CG04
Gene Symbols:
IGL, IGLC1, IGLV, IGLV1-51
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
28820, 3535, 3537, 3546
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
1-155-2
Conjugate:
Super Bright 436
Gene:
IGLV1-51
Gene Alias:
Bence Jones Protein, BJP, Clambda1, Ig lambda chain V-I region BL2, IgL, Igl@, IGLC, IGLC 1/2/3, IGLC1, Igl-C1, IGLL5, IGLV, IGLV@, immmunoglobulin lambda light chain variable region, Immunoglobulin L, immunoglobulin lambda chain complex, immunoglobulin lambda constant 1, immunoglobulin lambda constant 7, immunoglobulin lambda light chain, immunoglobulin lambda light chain constant region, immunoglobulin lambda light chain V-J region, immunoglobulin lambda variable cluster, Lambda LC, lambda-immunoglobulin, LOC100060608, Mcg Marker, Paraprotein
Host Species:
Mouse
Quantity:
25 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: Lambda light chain
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.: P01701, P0CG04
Gene Symbols: IGL, IGLC1, IGLV, IGLV1-51
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 28820, 3535, 3537, 3546
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: 1-155-2
Conjugate: Super Bright 436
Gene: IGLC1
Gene Alias: Bence Jones Protein, BJP, Clambda1, Ig lambda chain V-I region BL2, IgL, Igl@, IGLC, IGLC 1/2/3, IGLC1, Igl-C1, IGLL5, IGLV, IGLV@, immmunoglobulin lambda light chain variable region, Immunoglobulin L, immunoglobulin lambda chain complex, immunoglobulin lambda constant 1, immunoglobulin lambda constant 7, immunoglobulin lambda light chain, immunoglobulin lambda light chain constant region, immunoglobulin lambda light chain V-J region, immunoglobulin lambda variable cluster, Lambda LC, lambda-immunoglobulin, LOC100060608, Mcg Marker, Paraprotein
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Lambda light chain
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.:
P01701, P0CG04
Gene Symbols:
IGL, IGLC1, IGLV, IGLV1-51
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
28820, 3535, 3537, 3546
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
1-155-2
Conjugate:
Super Bright 436
Gene:
IGLC1
Gene Alias:
Bence Jones Protein, BJP, Clambda1, Ig lambda chain V-I region BL2, IgL, Igl@, IGLC, IGLC 1/2/3, IGLC1, Igl-C1, IGLL5, IGLV, IGLV@, immmunoglobulin lambda light chain variable region, Immunoglobulin L, immunoglobulin lambda chain complex, immunoglobulin lambda constant 1, immunoglobulin lambda constant 7, immunoglobulin lambda light chain, immunoglobulin lambda light chain constant region, immunoglobulin lambda light chain V-J region, immunoglobulin lambda variable cluster, Lambda LC, lambda-immunoglobulin, LOC100060608, Mcg Marker, Paraprotein
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: CD3
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: P04234, P07766, P09693, P20963
Gene Symbols: Cd247, Cd3d, CD3E, CD3g
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 915, 916, 917, 919
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: UCHT1
Conjugate: Super Bright 436
Gene: Cd247
Gene Alias: 4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 TCR complex; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD3
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
P04234, P07766, P09693, P20963
Gene Symbols:
Cd247, Cd3d, CD3E, CD3g
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
915, 916, 917, 919
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
UCHT1
Conjugate:
Super Bright 436
Gene:
Cd247
Gene Alias:
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 TCR complex; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ