63-059-642

CD59 (Protectin) Monoclonal Antibody (OV9A2), Super Bright™ 600, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

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Pack Size SKU Availability Price
Each of 1 63-059-642-Each-of-1 In Stock ₹ 15,828.60

63-059-642 - Each of 1

₹ 15,828.60

In Stock

Quantity

1

Base Price: ₹ 15,828.60

GST (18%): ₹ 2,849.148

Total Price: ₹ 18,677.748

Antigen

CD59 (Protectin)

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.

P13987

Gene Symbols

CD59

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

966

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

OV9A2

Conjugate

Super Bright 600

Gene

CD59

Gene Alias

16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; AA987121; Cb59b molecule; CD59; CD59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 glycoprotein; CD59 molecule; CD59 molecule (CD59 blood group); CD59 molecule, complement regulatory protein; Cd59a; CD59a antigen; CD59A glycoprotein; Cd59b; CD59b antigen; CD59B glycoprotein; CD59b moleucle, complement regulatory protein; complement inhibitor CD59; complement regulatory protein; EJ16; EJ30; EL32; G344; HRF20; HRF-20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MACIF; MAC-inhibitory protein; MACIP; MAC-IP; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; Membrane inhibitor of reactive lysis; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein

Host Species

Mouse

Quantity

100 Tests

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

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Description

  • Description: This OV9A2 monoclonal antibody reacts with human CD59, which is also known as Protectin
  • This GPI-linked membrane glycoprotein shares structural homology with the murine Ly-6 superfamily
  • CD59 is expressed on all human lymphocytes, monocytes, granulocytes, and erythrocytes
  • This protein is also expressed on non-hematopoietic cells, including endothelial cells and neurons
  • By binding the complement components C8 and C9, CD59 inhibits assembly of the membrane attack complex and cytolytic activity by complement
  • CD59 interacts with CD2 to modulate T cell adhesion, and also plays a role in T cell activation
  • Finally, altered expression of CD55 and CD59 on human peripheral blood cells has been observed in patients with systemic lupus erythematosus (SLE)
  • Crossblocking studies indicate that the OV9A2 monoclonal antibody binds the same epitope as MEM-43
  • Applications Reported: This OV9A2 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This OV9A2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
  • This can be used at 5 μL (0.5 μg) per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • Super Bright 600 is a tandem dye that can be excited with the violet laser line (405 nm) and emits at 600 nm
  • CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC)
  • CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade
  • CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane
  • Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction
  • CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation
  • Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction
  • Multiple alternatively spliced transcript variants of CD59 have been identified.

Compare Similar Items

Show Difference

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Fischer Scientific

63-059-642

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Antigen:
CD59 (Protectin)

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
P13987

Gene Symbols:
CD59

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
966

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
OV9A2

Conjugate:
Super Bright 600

Gene:
CD59

Gene Alias:
16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; AA987121; Cb59b molecule; CD59; CD59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 glycoprotein; CD59 molecule; CD59 molecule (CD59 blood group); CD59 molecule, complement regulatory protein; Cd59a; CD59a antigen; CD59A glycoprotein; Cd59b; CD59b antigen; CD59B glycoprotein; CD59b moleucle, complement regulatory protein; complement inhibitor CD59; complement regulatory protein; EJ16; EJ30; EL32; G344; HRF20; HRF-20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MACIF; MAC-inhibitory protein; MACIP; MAC-IP; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; Membrane inhibitor of reactive lysis; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein

Host Species:
Mouse

Quantity:
100 Tests

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1 κ

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Fischer Scientific

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Antigen:
CD62P (P-Selectin)

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2

Gene Accession No.:
P16109, Q01102

Gene Symbols:
SELP

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
20344, 6403

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
Psel.KO2.3

Conjugate:
Super Bright 600

Gene:
SELP

Gene Alias:
CD62, CD62 antigen-like family member P, CD62P, CD62P antigen, CD62P, CD62 homolog, FLJ45155, GMP140, GMP-140, GMRP, Granule membrane protein 140, granule membrane protein 140kDa, granulocyte membrane protein, Grmp, LECAM3, leukocyte-endothelial cell adhesion molecule 3, PADGEM, Platelet activation dependent granule-external membrane protein, platelet alpha-granule membrane protein, PSEL, PSELECT, P-selectin, P-selectin precursor, RP1-86F14.2, selectin P, selectin P (granule membrane protein 140kDa, antigen CD62), selectin, platelet, Selp

Host Species:
Mouse

Quantity:
25 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG1 κ

Img

Fischer Scientific

63-062-682

--


Antigen:
CD62P (P-Selectin)

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2

Gene Accession No.:
P16109, Q01102

Gene Symbols:
SELP

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
20344, 6403

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
Psel.KO2.3

Conjugate:
Super Bright 600

Gene:
SELP

Gene Alias:
CD62, CD62 antigen-like family member P, CD62P, CD62P antigen, CD62P, CD62 homolog, FLJ45155, GMP140, GMP-140, GMRP, Granule membrane protein 140, granule membrane protein 140kDa, granulocyte membrane protein, Grmp, LECAM3, leukocyte-endothelial cell adhesion molecule 3, PADGEM, Platelet activation dependent granule-external membrane protein, platelet alpha-granule membrane protein, PSEL, PSELECT, P-selectin, P-selectin precursor, RP1-86F14.2, selectin P, selectin P (granule membrane protein 140kDa, antigen CD62), selectin, platelet, Selp

Host Species:
Mouse

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG1 κ

Img

Invitrogen

63-062-942

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Antigen:
CD62L (L-Selectin)

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
P14151

Gene Symbols:
SELL

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
6402

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
DREG-56 (DREG56)

Conjugate:
Super Bright 600

Gene:
SELL

Gene Alias:
A.11; AI528707; CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LECAM1; LECAM-1; LEU8; Leu-8; Leukocyte adhesion molecule 1; leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; L-selectin; Ly22; Ly-22; LYAM1; Lyam-1; Ly-m22; Lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; pln homing receptor; PLNHR; SELE; selectin E (endothelial adhesion molecule 1); selectin L; selectin L (lymphocyte adhesion molecule 1); selectin, lymphocyte; Sell; TQ1

Host Species:
Mouse

Quantity:
100 Tests

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1 κ