Phospho-Tyrosine Hydroxylase (Ser40) Recombinant Rabbit Monoclonal Antibody (5H9L20), Invitrogen™

Description

• This antibody is predicted to react with Human, Monkey, Cat, Mouse
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine
• In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4)
• BH4 binds to the TH catalytic domain, resulting in enzymatic activity
• Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated
• These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains
• TH is also responsible for the conversion of L-tyrosine to L-dopa
• TH plays a key role in the physiology of adrenergic neurons
• The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.