7068124
CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), PE, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD223 (LAG-3)
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols
LAG3
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
LAG3
Clone
eBioC9B7W (C9B7W)
Applications
Flow Cytometry
Conjugate
PE
Host Species
Rat
Target Species
Mouse
Gene Accession No.
Q61790
Gene ID (Entrez)
16768
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: The eBioC9B7W monoclonal antibody recognizes mouse CD223 (LAG-3, LAG3) protein expressed by activated alpha/beta-TCR bearing T cells, a subset of gamma/delta-TCR bearing T cells and a subset of NK cells
- CD223 is a 70 kDa type I transmembrane protein with a structure that is similar to CD4
- However, a soluble form of human CD223 has been detected by ELISA in human serum, and data suggest that mouse CD223 is proteolytically cleaved in the D4 domain
- This results in a 54 kDa fragment containing all the extracellular domains, and a 16 kDa fragment containing the intracellular and transmembrane domains
- The 54 kDa can remain membrane-associated or be released as soluble CD223
- CD223 binds to MHC class II with higher affinity than CD4, and it is thought that this interaction is involved in the negative regulation of T-cell activation and homeostatic proliferation
- Furthermore, CD223 is expressed by CD4+CD25+ regulatory T cells, and it has been suggested that CD223 may be involved in their regulatory function
- Applications Reported: This eBioC9B7W (C9B7W) antibody has been reported for use in flow cytometric analysis
- Applications Tested: This eBioC9B7W (C9B7W) antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4
- LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation
- Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells
- CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells
- Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
Compare Similar Items
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Antigen: CD223 (LAG-3)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols: LAG3
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: LAG3
Clone: eBioC9B7W (C9B7W)
Applications: Flow Cytometry
Conjugate: PE
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q61790
Gene ID (Entrez): 16768
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD223 (LAG-3)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols:
LAG3
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
LAG3
Clone:
eBioC9B7W (C9B7W)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q61790
Gene ID (Entrez):
16768
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD244.2 (2B4)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: 2B4; C9.1; Cd244; CD244 long isoform; CD244 natural killer cell receptor 2B4; CD244 short isoform; F730046O15Rik; Ly90; NAIL; natural killer cell receptor; natural killer cell receptor 2B4; NK cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; Nmrk; non MHC restricted killing associated; non-MHC restricted killing associated; Signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4
Gene Symbols: Cd244
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Cd244
Clone: eBio244F4
Applications: Flow Cytometry
Conjugate: PE
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q07763
Gene ID (Entrez): 18106
Isotype: IgG2a
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD244.2 (2B4)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
2B4; C9.1; Cd244; CD244 long isoform; CD244 natural killer cell receptor 2B4; CD244 short isoform; F730046O15Rik; Ly90; NAIL; natural killer cell receptor; natural killer cell receptor 2B4; NK cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; Nmrk; non MHC restricted killing associated; non-MHC restricted killing associated; Signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4
Gene Symbols:
Cd244
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
Cd244
Clone:
eBio244F4
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q07763
Gene ID (Entrez):
18106
Isotype:
IgG2a
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD305 (LAIR1)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: 5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; Lair-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1
Gene Symbols: LAIR1
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: LAIR1
Clone: 113
Applications: Flow Cytometry
Conjugate: PE
Host Species: Armenian Hamster
Target Species: Mouse
Gene Accession No.: Q8BG84
Gene ID (Entrez): 52855
Isotype: IgG
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD305 (LAIR1)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; Lair-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1
Gene Symbols:
LAIR1
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
LAIR1
Clone:
113
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Armenian Hamster
Target Species:
Mouse
Gene Accession No.:
Q8BG84
Gene ID (Entrez):
52855
Isotype:
IgG
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD317 (BST2, PDCA-1)
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: 2310015I10Rik; bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; Bst2; BST-2; C87040; CD317; Damp1; DAMP-1; DAMP-1 protein homolog; GREG; HM1.24 antigen; NPC-A-7; PDCA-1; protein DAMP-1; TETHERIN
Gene Symbols: Bst2
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Bst2
Clone: eBio927
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q8R2Q8
Gene ID (Entrez): 69550
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD317 (BST2, PDCA-1)
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
2310015I10Rik; bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; Bst2; BST-2; C87040; CD317; Damp1; DAMP-1; DAMP-1 protein homolog; GREG; HM1.24 antigen; NPC-A-7; PDCA-1; protein DAMP-1; TETHERIN
Gene Symbols:
Bst2
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
Bst2
Clone:
eBio927
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q8R2Q8
Gene ID (Entrez):
69550
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Product Type:
Antibody