7069493

NK1.1 Monoclonal Antibody (PK136), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

NK1.1

Concentration

0.5 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Alias

AI462337; CD161; CD161 antigen-like family member B; CD161 antigen-like family member C; CD161b; CD161c; EMBL:AAQ11375.1}; Inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1C; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; KLRB1; Klrb1b; klrb1b {ECO:0000312; Klrb1c; Klrb1d; Klrb1f; klrb1f {ECO:0000250; Ly55; Ly-55; Ly55b; ly-55b; Ly55c; ly-55c; Ly55d; Ly-55d; Ly59; Ly-59; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus C; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55b; lymphocyte antigen 55c; Lymphocyte antigen 55d; lymphocyte antigen 59; MGC163757; MGC163759; natural killer cell receptor protein NKR-P1B; natural killer cell receptor protein NKR-P1C; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; natural killer cell surface protein NKR-P1F; Natural killer cell surface protein P1-40; natural killer cell-associated antigen 1; natural killer cells; nk cells; Nk1; Nk-1; NK1.1; Nk1.2; Nk-1.2; NKRP1; NK-RP1; NKR-P1 34; NKR-P1 40; NKR-P1.9; NKRP140; Nkrp1b; NKR-P1B; Nkrp1-b; NKR-P1B protein; Nkrp1c; NKR-P1C; Nkrp1d; NKR-P1D; Nkrp1f; NKR-P1F; RGD:2975}; UniProtKB:Q8VD98}

Gene Symbols

Klrb1b, Klrb1c

Primary or Secondary

Primary

Content And Storage

4° C

Clone

PK136

Applications

Flow Cytometry, Immunoprecipitation

Conjugate

Unconjugated

Host Species

Mouse

Target Species

Mouse

Gene Accession No.

P27812, P27814

Gene ID (Entrez)

17059, 80782

Isotype

IgG2a κ

Purification Method

Affinity chromatography

Product Type

Antibody

Related Products

Img

Fischer Scientific

7068294

Mouse Monoclonal Antibody...

Img

Fischer Scientific

7069296

Rat Monoclonal Antibody...

Img

Fischer Scientific

7069298

Rat Monoclonal Antibody...

Img

Fischer Scientific

7069250

Rat Monoclonal Antibody...

Img

Fischer Scientific

7069245

Rat Monoclonal Antibody...

Img

Fischer Scientific

7068771

Mouse Monoclonal Antibody...

Img

Fischer Scientific

7068602

Mouse Monoclonal Antibody...

Img

Fischer Scientific

7068815

Rat Monoclonal Antibody...

Description

  • Description: The PK136 monoclonal antibody reacts with mouse NK1.1, an antigen expressed by natural killer cells and a subset of T cells in the NK1.1 mouse strains including C57BL and NZB
  • Several commonly used laboratory mouse strains such as BALB/c, SJL, AKR, CBA, C3H and A do not express the NK1.1 antigen
  • For detection of NK cells in these strains the monoclonal antibody DX5 (Cat
  • No
  • 14-5971) should be used
  • Simultaneous staining of C57BL/6 spleen cells with PK136 and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells
  • Applications Reported: PK136 can be used for flow cytometric analysis, immunoprecipitation, depletion of NK cells, and in vitro functional studies
  • (Please use Functional Grade purified PK136, cat
  • 16-5941, for functional studies.)
  • Applications Tested: The PK136 antibody has been tested by flow cytometric analysis of C57Bl/6 mouse splenocytes and can be used at less than or equal to 0.5 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Aggregation: Less than 10%, as determined by HPLC
  • NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation
  • Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function
  • The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain
  • The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus
  • NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

Compare Similar Items

Show Difference

Img

Fischer Scientific

7069493

Mouse Monoclonal Antibody...


Antigen:
NK1.1

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
AI462337; CD161; CD161 antigen-like family member B; CD161 antigen-like family member C; CD161b; CD161c; EMBL:AAQ11375.1}; Inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1C; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; KLRB1; Klrb1b; klrb1b {ECO:0000312; Klrb1c; Klrb1d; Klrb1f; klrb1f {ECO:0000250; Ly55; Ly-55; Ly55b; ly-55b; Ly55c; ly-55c; Ly55d; Ly-55d; Ly59; Ly-59; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus C; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55b; lymphocyte antigen 55c; Lymphocyte antigen 55d; lymphocyte antigen 59; MGC163757; MGC163759; natural killer cell receptor protein NKR-P1B; natural killer cell receptor protein NKR-P1C; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; natural killer cell surface protein NKR-P1F; Natural killer cell surface protein P1-40; natural killer cell-associated antigen 1; natural killer cells; nk cells; Nk1; Nk-1; NK1.1; Nk1.2; Nk-1.2; NKRP1; NK-RP1; NKR-P1 34; NKR-P1 40; NKR-P1.9; NKRP140; Nkrp1b; NKR-P1B; Nkrp1-b; NKR-P1B protein; Nkrp1c; NKR-P1C; Nkrp1d; NKR-P1D; Nkrp1f; NKR-P1F; RGD:2975}; UniProtKB:Q8VD98}

Gene Symbols:
Klrb1b, Klrb1c

Primary or Secondary:
Primary

Content And Storage:
4° C

Clone:
PK136

Applications:
Flow Cytometry, Immunoprecipitation

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Mouse

Gene Accession No.:
P27812, P27814

Gene ID (Entrez):
17059, 80782

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Img

Fischer Scientific

7069494

Rat Monoclonal Antibody...


Antigen:
CD253 (TRAIL)

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
A330042I21Rik; AI448571; Apo-2 ligand; APO2L; Apo-2L; CD253; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; Ly81; Protein TRAIL; TL2; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; Tnfsf10; TNLG6A; TRAIL; TRAIL protein; TRAIL/APO2L; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10

Gene Symbols:
TNFSF10

Primary or Secondary:
Primary

Content And Storage:
4° C

Clone:
N2B2

Applications:
Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization

Conjugate:
Unconjugated

Host Species:
Rat

Target Species:
Mouse

Gene Accession No.:
P50592

Gene ID (Entrez):
22035

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Img

Fischer Scientific

7069496

Rat Monoclonal Antibody...


Antigen:
AID

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
activation induced deaminase; activation-induced cytidine deaminase; Aicda; AID; Arp2; CDA2; Cytidine aminohydrolase; epididymis secretory protein Li 284; HEL-S-284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; single-stranded DNA cytosine deaminase

Gene Symbols:
Aicda

Primary or Secondary:
Primary

Content And Storage:
4° C

Clone:
mAID-2

Applications:
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot

Conjugate:
Unconjugated

Host Species:
Rat

Target Species:
Human, Mouse

Gene Accession No.:
Q9GZX7, Q9WVE0

Gene ID (Entrez):
11628, 57379

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Img

Fischer Scientific

7069497

Armenian Hamster Monoclonal Antibod...


Antigen:
TCR beta

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
__

Gene Alias:
__

Gene Symbols:
Tcrb

Primary or Secondary:
Primary

Content And Storage:
4° C

Clone:
H57-597

Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry

Conjugate:
Unconjugated

Host Species:
Armenian Hamster

Target Species:
Mouse

Gene Accession No.:
__

Gene ID (Entrez):
21577

Isotype:
IgG

Purification Method:
Affinity chromatography

Product Type:
Antibody