7069562
IL-10 Monoclonal Antibody (JES5-16E3), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
IL-10
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Gene Symbols
IL10
Primary or Secondary
Primary
Content And Storage
4° C
Gene
IL10
Clone
JES5-16E3
Applications
Immunostaining
Conjugate
Unconjugated
Host Species
Rat
Target Species
Mouse
Gene Accession No.
P18893
Gene ID (Entrez)
16153
Isotype
IgG2b κ
Purification Method
Affinity chromatography
Product Type
Antibody
Description
- Description: The JES5-16E3 antibody reacts with mouse interleukin-10 (IL-10)
- Mouse IL-10 is an ∽18 kDa factor also known as Cytokine Synthesis Inhibitory Factor (CSIF)
- In the mouse, Th2 cells, B1 cells, macrophages, and keratinocytes are the major cell subsets that produce IL-10
- IL-10 inhibits synthesis of Th1 cytokines and proliferation of T cells, and acts as a costimulatory signal for mast cells, developing thymocytes and the Th2 response
- Applications Reported: The JES5-16E3 antibody has been reported for use in capture of mouse IL-10 by ELISA and ELISPOT, intracellular staining for flow cytometric analysis, IHC, and neutralization of IL-10 bioactivity
- Applications Tested: The JES5-16E3 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse Interleukin-10 (IL-10) in combination with the biotin JES5-2A5 (13-7102) antibody for detection and recombinant mouse IL-10 (14-8101) as the standard
- A suitable range of concentrations of this antibody for ELISA capture is 1-4 μg/mL
- A standard curve consisting of doubling dilutions of the recombinant standard over the range of 4000 pg/mL - 30 pg/mL should be included in each ELISA plate
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes
- This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages
- It also enhances B cell survival, proliferation, and antibody production
- Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway
- Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract
- Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis
- Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
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Antigen: IL-10
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Gene Symbols: IL10
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: IL10
Clone: JES5-16E3
Applications: Immunostaining
Conjugate: Unconjugated
Host Species: Rat
Target Species: Mouse
Gene Accession No.: P18893
Gene ID (Entrez): 16153
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
IL-10
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Gene Symbols:
IL10
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
IL10
Clone:
JES5-16E3
Applications:
Immunostaining
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
P18893
Gene ID (Entrez):
16153
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: IL-23 p19
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
Gene Symbols: IL23A
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: IL23A
Clone: 5B2
Applications: ELISA
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Mouse
Gene Accession No.: Q9EQ14
Gene ID (Entrez): 83430
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
IL-23 p19
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
Gene Symbols:
IL23A
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
IL23A
Clone:
5B2
Applications:
ELISA
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Mouse
Gene Accession No.:
Q9EQ14
Gene ID (Entrez):
83430
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: __
Concentration: __
Classification: __
Form: __
Regulatory Status: __
Formulation: __
Gene Alias: __
Gene Symbols: __
Primary or Secondary: __
Content And Storage: __
Gene: __
Clone: __
Applications: __
Conjugate: __
Host Species: __
Target Species: __
Gene Accession No.: __
Gene ID (Entrez): __
Isotype: __
Purification Method: __
Product Type: __
Antigen:
__
Concentration:
__
Classification:
__
Form:
__
Regulatory Status:
__
Formulation:
__
Gene Alias:
__
Gene Symbols:
__
Primary or Secondary:
__
Content And Storage:
__
Gene:
__
Clone:
__
Applications:
__
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__
Host Species:
__
Target Species:
__
Gene Accession No.:
__
Gene ID (Entrez):
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Isotype:
__
Purification Method:
__
Product Type:
__
Antigen: IFN gamma
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
Gene Symbols: IFNG
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: IFNG
Clone: NIB42
Applications: ELISA
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human
Gene Accession No.: P01579
Gene ID (Entrez): 3458
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
IFN gamma
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
Gene Symbols:
IFNG
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
IFNG
Clone:
NIB42
Applications:
ELISA
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
P01579
Gene ID (Entrez):
3458
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody