7069714
FOXJ1 Monoclonal Antibody (2A5), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
FOXJ1
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
FKHL13; FKHL-13; fork head homologue 4; forkhead box J1; forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; forkhead-related protein FKHL13; Foxj1; Hepatocyte nuclear factor 3 forkhead homolog 4; Hfh4; HFH-4; HNF-3/forkhead homolog 4; MGC35202
Gene Symbols
FOXJ1
Primary or Secondary
Primary
Content And Storage
4° C
Gene
FOXJ1
Clone
2A5
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse
Gene Accession No.
Q61660, Q92949
Gene ID (Entrez)
15223, 2302
Isotype
IgG1
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: This 2A5 monoclonal antibody reacts with Foxj1, a 50-kDa member of the Forkhead-box (FOX) family of winged-helix transcription factors
- Expression of Foxj1 is high in ciliated epithelial cells and low in naive T and B cells, where cellular activation results in downregulation of the factor
- Foxj1 modulates germinal center formation and Th1 activation by repressing NFkappaB through IkappaBbeta induction
- As such, this transcription factor has been suggested to antagonize autoimmune reactions such as systemic lupus erythematosus and rheumatoid arthritis
- In addition, Foxj1 has been linked to the formation of motile cilia in epithelial cells
- Applications Reported: This 2A5 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry
- Applications Tested: This 2A5 antibody has been tested by western blot of mouse tracheal epithelial cells and testes, as well as by immunohistochemistry of mouse lung tissue
- This antibody can be used between 1-10 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity
- FOXJ1 also inhibits the humoral immune response in B cells
- FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations
- Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases
- FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton
- FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.
Compare Similar Items
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Antigen: FOXJ1
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: FKHL13; FKHL-13; fork head homologue 4; forkhead box J1; forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; forkhead-related protein FKHL13; Foxj1; Hepatocyte nuclear factor 3 forkhead homolog 4; Hfh4; HFH-4; HNF-3/forkhead homolog 4; MGC35202
Gene Symbols: FOXJ1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: FOXJ1
Clone: 2A5
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human, Mouse
Gene Accession No.: Q61660, Q92949
Gene ID (Entrez): 15223, 2302
Isotype: IgG1
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
FOXJ1
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
FKHL13; FKHL-13; fork head homologue 4; forkhead box J1; forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; forkhead-related protein FKHL13; Foxj1; Hepatocyte nuclear factor 3 forkhead homolog 4; Hfh4; HFH-4; HNF-3/forkhead homolog 4; MGC35202
Gene Symbols:
FOXJ1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
FOXJ1
Clone:
2A5
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human, Mouse
Gene Accession No.:
Q61660, Q92949
Gene ID (Entrez):
15223, 2302
Isotype:
IgG1
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD273 (B7-DC)
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; Pdcd1lg2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2
Gene Symbols: PDCD1LG2
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: PDCD1LG2
Clone: 122
Applications: Flow Cytometry
Conjugate: Unconjugated
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q9WUL5
Gene ID (Entrez): 58205
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD273 (B7-DC)
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; Pdcd1lg2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2
Gene Symbols:
PDCD1LG2
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
PDCD1LG2
Clone:
122
Applications:
Flow Cytometry
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q9WUL5
Gene ID (Entrez):
58205
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: Gata-4
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: ASD2; DNA-binding protein GATA-GT2; GAT4; GATA binding protein 4; GATA4; Gata-4; GATA-binding factor 4; GATA-binding protein 4; MGC126629; TACHD; TOF; Transcription factor GATA-4; VSD1
Gene Symbols: GATA4
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: GATA4
Clone: eBioEvan
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Rat
Target Species: Human, Mouse
Gene Accession No.: P43694, Q08369
Gene ID (Entrez): 14463, 2626
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
Gata-4
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
ASD2; DNA-binding protein GATA-GT2; GAT4; GATA binding protein 4; GATA4; Gata-4; GATA-binding factor 4; GATA-binding protein 4; MGC126629; TACHD; TOF; Transcription factor GATA-4; VSD1
Gene Symbols:
GATA4
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
GATA4
Clone:
eBioEvan
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Human, Mouse
Gene Accession No.:
P43694, Q08369
Gene ID (Entrez):
14463, 2626
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD279 (PD-1)
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Gene Symbols: Pdcd1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Pdcd1
Clone: RMP1-30
Applications: Flow Cytometry
Conjugate: Unconjugated
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q02242
Gene ID (Entrez): 18566
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD279 (PD-1)
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Gene Symbols:
Pdcd1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Pdcd1
Clone:
RMP1-30
Applications:
Flow Cytometry
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q02242
Gene ID (Entrez):
18566
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Product Type:
Antibody