7069892
KLRG1 Monoclonal Antibody (2F1), Functional Grade, eBioscience™, Invitrogen™
Syrian Hamster Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
KLRG1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative; pH 7.2
Gene Alias
2F1; 2F1-Ag; CLEC15A; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; killer cell lectin like receptor G1; killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; Klrg1; Mafa; MAFA-2F1; MAFAL; MAFA-L; MAFA-LIKE; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); mast cell function-associated antigen 2F1; natural killer cell receptor
Gene Symbols
Klrg1
Primary or Secondary
Primary
Content And Storage
4° C
Gene
Klrg1
Clone
2F1
Applications
Flow Cytometry, Functional Assay
Conjugate
Functional Grade
Host Species
Syrian Hamster
Target Species
Mouse
Gene Accession No.
O88713
Gene ID (Entrez)
50928
Isotype
IgG
Purification Method
Affinity chromatography
Product Type
Antibody
Description
- Description: This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA)
- KLRG1 is a homodimer of glycosylated 30-38 kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM)
- Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells
- This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells
- MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling
- Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct
- Applications Reported: 2F1 has been reported for use in flow cytometric analysis and functional assays
- Applications Tested: The 2F1 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This can be used at less than or equal to 1 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family whose members contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains
- These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1
- KLRG1 is an inhibitory receptor that is expressed on natural killer (NK) cells and certain T cells
- NK cells are involved in the lysis of tumor cells and virus-infected cells, and mediate humoral and cell-mediated immune responses.
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Antigen: KLRG1
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: 2F1; 2F1-Ag; CLEC15A; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; killer cell lectin like receptor G1; killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; Klrg1; Mafa; MAFA-2F1; MAFAL; MAFA-L; MAFA-LIKE; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); mast cell function-associated antigen 2F1; natural killer cell receptor
Gene Symbols: Klrg1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Klrg1
Clone: 2F1
Applications: Flow Cytometry, Functional Assay
Conjugate: Functional Grade
Host Species: Syrian Hamster
Target Species: Mouse
Gene Accession No.: O88713
Gene ID (Entrez): 50928
Isotype: IgG
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
KLRG1
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
2F1; 2F1-Ag; CLEC15A; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; killer cell lectin like receptor G1; killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; Klrg1; Mafa; MAFA-2F1; MAFAL; MAFA-L; MAFA-LIKE; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); mast cell function-associated antigen 2F1; natural killer cell receptor
Gene Symbols:
Klrg1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Klrg1
Clone:
2F1
Applications:
Flow Cytometry, Functional Assay
Conjugate:
Functional Grade
Host Species:
Syrian Hamster
Target Species:
Mouse
Gene Accession No.:
O88713
Gene ID (Entrez):
50928
Isotype:
IgG
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: FceR1 alpha
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
Gene Symbols: FCER1A
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: FCER1A
Clone: MAR-1
Applications: Flow Cytometry, Functional Assay, Neutralization
Conjugate: Functional Grade
Host Species: Armenian Hamster
Target Species: Mouse
Gene Accession No.: P20489
Gene ID (Entrez): 14125
Isotype: IgG
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
FceR1 alpha
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
Gene Symbols:
FCER1A
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
FCER1A
Clone:
MAR-1
Applications:
Flow Cytometry, Functional Assay, Neutralization
Conjugate:
Functional Grade
Host Species:
Armenian Hamster
Target Species:
Mouse
Gene Accession No.:
P20489
Gene ID (Entrez):
14125
Isotype:
IgG
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD276 (B7-H3)
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: 4Ig-B7-H3; 6030411F23Rik; AU016588; B7 homolog 3; B7h3; B7-H3; B7RP-2; CD276; CD276 antigen; CD276 molecule; CD276 molecule tv1; costimulatory molecule; PSEC0249; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; UNQ309/PRO352
Gene Symbols: CD276
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: CD276
Clone: MIH35
Applications: Flow Cytometry, Functional Assay
Conjugate: Functional Grade
Host Species: Rat
Target Species: Human, Mouse
Gene Accession No.: Q5ZPR3, Q8VE98
Gene ID (Entrez): 102657, 80381
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD276 (B7-H3)
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
4Ig-B7-H3; 6030411F23Rik; AU016588; B7 homolog 3; B7h3; B7-H3; B7RP-2; CD276; CD276 antigen; CD276 molecule; CD276 molecule tv1; costimulatory molecule; PSEC0249; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; UNQ309/PRO352
Gene Symbols:
CD276
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
CD276
Clone:
MIH35
Applications:
Flow Cytometry, Functional Assay
Conjugate:
Functional Grade
Host Species:
Rat
Target Species:
Human, Mouse
Gene Accession No.:
Q5ZPR3, Q8VE98
Gene ID (Entrez):
102657, 80381
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: NK1.1
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: __
Gene Symbols: __
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: __
Clone: PK136
Applications: Flow Cytometry, Functional Assay
Conjugate: Functional Grade
Host Species: Mouse
Target Species: Mouse
Gene Accession No.: __
Gene ID (Entrez): __
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
NK1.1
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
__
Gene Symbols:
__
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
__
Clone:
PK136
Applications:
Flow Cytometry, Functional Assay
Conjugate:
Functional Grade
Host Species:
Mouse
Target Species:
Mouse
Gene Accession No.:
__
Gene ID (Entrez):
__
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody