7069942
CD217 (IL-17Ra) Monoclonal Antibody (424LTS), Functional Grade, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD217 (IL-17Ra)
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative; pH 7.2
Gene Alias
AW538159; CANDF5; CD127; CD217; CDw217; hIL-17R; IL-17 receptor A; IL17R; Il17ra; IL-17RA; interleukin 17 receptor A; interleukin-17 receptor A; MGC10262; VDw217
Gene Symbols
Il17ra
Primary or Secondary
Primary
Content And Storage
4° C
Gene
Il17ra
Clone
424LTS
Applications
Functional Assay, Neutralization
Conjugate
Functional Grade
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q96F46
Gene ID (Entrez)
23765
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Description
- Description: The 424LTS monoclonal antibody reacts with and blocks IL-17A binding to human interleukin 17 receptor A (IL-17RA, IL-17R)
- IL-17RA is a type I membrane protein of approximately 96 kDa (866 amino acids) and is involved in inflammatory responses to IL-17A, IL-17F and IL-17AF heterodimer
- It forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling
- IL-17RA is ubiquitously expressed, but in leukocytes its expression is elevated on granulocytes and monocytes
- Applications Reported: This 424LTS antibody has been reported for use in blocking IL-17 receptor A ligand binding
- Applications Tested: The ND50 of 424LTS as measured by the inhibition of IL-6 induction in NHDF cells is 1-5 μg/mL in the presence of 3 ng/mL of recombinant Human IL-17A
- Neutralization dose will vary depending on assay method, cytokine concentration, and cell type
- This antibody should be carefully titrated for optimal performance in the assay of interest
- Storage and handling: Use in a sterile environment
- Filtration: 0.2 μm post-manufacturing filtered
- Purity: Greater than 90%, as determined by SDS-PAGE
- Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay
- Aggregation: Less than 10%, as determined by HPLC
- Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes
- It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils
- IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F
- IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis
- Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
Compare Similar Items
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Antigen: CD217 (IL-17Ra)
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: AW538159; CANDF5; CD127; CD217; CDw217; hIL-17R; IL-17 receptor A; IL17R; Il17ra; IL-17RA; interleukin 17 receptor A; interleukin-17 receptor A; MGC10262; VDw217
Gene Symbols: Il17ra
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Il17ra
Clone: 424LTS
Applications: Functional Assay, Neutralization
Conjugate: Functional Grade
Host Species: Mouse
Target Species: Human
Gene Accession No.: Q96F46
Gene ID (Entrez): 23765
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD217 (IL-17Ra)
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
AW538159; CANDF5; CD127; CD217; CDw217; hIL-17R; IL-17 receptor A; IL17R; Il17ra; IL-17RA; interleukin 17 receptor A; interleukin-17 receptor A; MGC10262; VDw217
Gene Symbols:
Il17ra
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Il17ra
Clone:
424LTS
Applications:
Functional Assay, Neutralization
Conjugate:
Functional Grade
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
Q96F46
Gene ID (Entrez):
23765
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD282 (TLR2)
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll-like receptor; toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; toll-like-receptor 2, exon 1a_; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a
Gene Symbols: Tlr2
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Tlr2
Clone: 6C2
Applications: Control, Flow Cytometry, Functional Assay
Conjugate: Functional Grade
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q9QUN7
Gene ID (Entrez): 24088
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD282 (TLR2)
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll-like receptor; toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; toll-like-receptor 2, exon 1a_; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a
Gene Symbols:
Tlr2
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Tlr2
Clone:
6C2
Applications:
Control, Flow Cytometry, Functional Assay
Conjugate:
Functional Grade
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q9QUN7
Gene ID (Entrez):
24088
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD200 Receptor
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; CD200 R1; CD200 receptor 1; CD200R; Cd200r1; Cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200; CRTR2; HCRTR2; MOX2 receptor; MOX2R; Orexin receptor 2; OX102 antigen; OX2 receptor; OX2R; UNQ2522/PRO6015
Gene Symbols: CD200R1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: CD200R1
Clone: OX108
Applications: Flow Cytometry, Functional Assay
Conjugate: Functional Grade
Host Species: Mouse
Target Species: Human
Gene Accession No.: Q8TD46
Gene ID (Entrez): 131450
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD200 Receptor
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; CD200 R1; CD200 receptor 1; CD200R; Cd200r1; Cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200; CRTR2; HCRTR2; MOX2 receptor; MOX2R; Orexin receptor 2; OX102 antigen; OX2 receptor; OX2R; UNQ2522/PRO6015
Gene Symbols:
CD200R1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
CD200R1
Clone:
OX108
Applications:
Flow Cytometry, Functional Assay
Conjugate:
Functional Grade
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
Q8TD46
Gene ID (Entrez):
131450
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: TIGIT
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Gene Symbols: TIGIT
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: TIGIT
Clone: MBSA43
Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin)
Conjugate: Functional Grade
Host Species: Mouse
Target Species: Human
Gene Accession No.: Q495A1
Gene ID (Entrez): 201633
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
TIGIT
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Gene Symbols:
TIGIT
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
TIGIT
Clone:
MBSA43
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin)
Conjugate:
Functional Grade
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
Q495A1
Gene ID (Entrez):
201633
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody