7090229

IL-22 Monoclonal Antibody (IL22JOP), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

IL-22

Concentration

0.2 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Alias

Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18

Gene Symbols

IL22

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Gene

IL22

Clone

IL22JOP

Applications

Flow Cytometry

Conjugate

APC

Host Species

Rat

Target Species

Human, Mouse, Rhesus Monkey

Gene Accession No.

Q9GZX6, Q9JJY9

Gene ID (Entrez)

50616, 50929, 718047

Isotype

IgG2a κ

Purification Method

Affinity chromatography

Product Type

Antibody

Description

  • Description: The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22
  • IL-22 is a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells
  • Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells
  • This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo
  • Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut
  • Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients
  • Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis
  • IL22JOP is published to recognize rhesus IL-22
  • Applications Reported: This IL22JOP antibody has been reported for use in intracellular staining followed by flow cytometric analysis
  • Applications Tested: This IL22JOP antibody has been tested on Th17-polarized CD4+ normal human peripheral blood cells
  • This can be used at less than or equal to 0.25 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • IL-22 also known as IL-10-related T-cell derived inducible factor, is an alpha helical cytokine and is considered a member of the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and the type I and II interferons
  • IL-22 is produced mainly by activated T cells and NK cells
  • In humans, the IL-22 gene is located on the q arm of chromosome 12, and is structurally related to IL10
  • IL-22 acts by engaging the heterodimeric receptor complex consisting of primary receptor IL-22R1 and accessory receptor IL-10R2
  • IL-22R1 also binds IL-20 and IL-24; IL-10R2 also binds IL-10, IL-27, IL-28, and IL-29
  • Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway
  • In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling
  • IL-22 appears not to directly influence immune cells, and major targets of the cytokine appear to be nonimmune cells, such as cells of the skin, digestive and respiratory system, as well as hepatocytes, and keratinocytes
  • IL-22 has been described as an effector cytokine of the Th17 lineage
  • Along with IL-17A and IL-17F, IL-22 regulates genes associated with innate immunity of the skin
  • IL-17A, IL-17F and IL-22 are all co-expressed by Th17 cells, however, they are differentially regulated
  • The effects of IL-22 include induction of acute phase reactants and antimicrobial proteins, as well as increasing the mobility of keratinocytes
  • IL-22 is highly expressed during chronic inflammation, and found to activate intracellular kinases and transcription factors
  • IL-22 is critical for host defense against infections of extracellular pathogens, and promotes wound-healing responses
  • IL-22 is upregulated in activated T cells
  • IL-22 has been reported to mediate IL-23-induced acanthosis and dermal inflammation through activation of STAT3.

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Fischer Scientific

7090229

Rat Monoclonal Antibody...


Antigen:
IL-22

Concentration:
0.2 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18

Gene Symbols:
IL22

Primary or Secondary:
Primary

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Gene:
IL22

Clone:
IL22JOP

Applications:
Flow Cytometry

Conjugate:
APC

Host Species:
Rat

Target Species:
Human, Mouse, Rhesus Monkey

Gene Accession No.:
Q9GZX6, Q9JJY9

Gene ID (Entrez):
50616, 50929, 718047

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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Fischer Scientific

7090230

Rat Monoclonal Antibody...


Antigen:
IFN gamma

Concentration:
0.2 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g

Gene Symbols:
IFNG

Primary or Secondary:
Primary

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Gene:
IFNG

Clone:
XMG1.2

Applications:
Flow Cytometry

Conjugate:
APC

Host Species:
Rat

Target Species:
Mouse

Gene Accession No.:
P01580

Gene ID (Entrez):
15978

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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Fischer Scientific

7090231

Mouse Monoclonal Antibody...


Antigen:
IFN gamma

Concentration:
__

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
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Gene Alias:
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g

Gene Symbols:
IFNG

Primary or Secondary:
Primary

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Gene:
IFNG

Clone:
4S.B3

Applications:
Flow Cytometry

Conjugate:
APC

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
P01579

Gene ID (Entrez):
3458

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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Antigen:
TNF alpha

Concentration:
__

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
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Gene Alias:
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor

Gene Symbols:
Tnf

Primary or Secondary:
Primary

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Gene:
Tnf

Clone:
MAb11

Applications:
Flow Cytometry

Conjugate:
APC

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
P01375

Gene ID (Entrez):
7124

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody