7091457
AIRE Monoclonal Antibody (5H12), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
AIRE
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
Gene Symbols
Aire
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
Aire
Clone
5H12
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate
Alexa Fluor 488
Host Species
Rat
Target Species
Mouse
Gene Accession No.
Q9Z0E3
Gene ID (Entrez)
11634
Isotype
IgG2c κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE)
- This 58-kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs)
- However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells
- Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection
- Other biological functions for AIRE include chemokine expression and antigen presentation
- The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2
- Applications Reported: This 5H12 antibody has been reported for use in flow cytometric analysis and immunohistochemical staining of frozen tissue sections (IHC-F)
- Applications Tested: This 5H12 antibody has been tested by immunohistochemistry on fixed, frozen mouse thymus at less than or equal to 10 μg/mL
- It is recommended that this antibody be carefully titrated for optimal performance in the assay of interest
- Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser
- Filtration: 0.2 μm post-manufacturing filtered
- AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression
- A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes
- It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP
- Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD)
- AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity
- Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Compare Similar Items
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Antigen: AIRE
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
Gene Symbols: Aire
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Aire
Clone: 5H12
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate: Alexa Fluor 488
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q9Z0E3
Gene ID (Entrez): 11634
Isotype: IgG2c κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
AIRE
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
Gene Symbols:
Aire
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
Aire
Clone:
5H12
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate:
Alexa Fluor 488
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q9Z0E3
Gene ID (Entrez):
11634
Isotype:
IgG2c κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: Neural/Glial Antigen 2 (NG2)
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: 4732461B14Rik; AN2; AN2 proteoglycan; AN2/NG2 proteoglycan; chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); chondroitin sulfate proteoglycan NG2; CSPG4; HMW MAA; HMW-MAA; HSN tumor-specific antigen; Kiaa4232; MCSP; MCSPG; MEL CSPG; melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; MEL-CSPG; membrane-spanning proteoglycan NG2; MSK16; nerve/glial antigen 2; Ng2; Proteoglycan AN2
Gene Symbols: Cspg4
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Cspg4
Clone: 9.2.27
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin)
Conjugate: Alexa Fluor 488
Host Species: Mouse
Target Species: Human
Gene Accession No.: Q6UVK1
Gene ID (Entrez): 1464
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
Neural/Glial Antigen 2 (NG2)
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
4732461B14Rik; AN2; AN2 proteoglycan; AN2/NG2 proteoglycan; chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); chondroitin sulfate proteoglycan NG2; CSPG4; HMW MAA; HMW-MAA; HSN tumor-specific antigen; Kiaa4232; MCSP; MCSPG; MEL CSPG; melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; MEL-CSPG; membrane-spanning proteoglycan NG2; MSK16; nerve/glial antigen 2; Ng2; Proteoglycan AN2
Gene Symbols:
Cspg4
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
Cspg4
Clone:
9.2.27
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin)
Conjugate:
Alexa Fluor 488
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
Q6UVK1
Gene ID (Entrez):
1464
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: IL-23 p19
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
Gene Symbols: IL23A
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: IL23A
Clone: fc23cpg
Applications: Flow Cytometry
Conjugate: Alexa Fluor 488
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q9EQ14
Gene ID (Entrez): 83430
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
IL-23 p19
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
Gene Symbols:
IL23A
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
IL23A
Clone:
fc23cpg
Applications:
Flow Cytometry
Conjugate:
Alexa Fluor 488
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q9EQ14
Gene ID (Entrez):
83430
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: IL-4
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
Gene Symbols: Il4
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Il4
Clone: 11B11
Applications: Flow Cytometry
Conjugate: Alexa Fluor 488
Host Species: Rat
Target Species: Mouse
Gene Accession No.: P07750
Gene ID (Entrez): 16189
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
IL-4
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
Gene Symbols:
Il4
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
Il4
Clone:
11B11
Applications:
Flow Cytometry
Conjugate:
Alexa Fluor 488
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
P07750
Gene ID (Entrez):
16189
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody