7092728
Granzyme B Mouse anti-Human, FITC, Clone: GB11, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Granzyme B
Applications
Flow Cytometry
Conjugate
FITC
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Clone
GB11
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human Granzyme B
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Description The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa
- Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin
- In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes
- Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis
- Granzyme B may also be involved in the hydrolysis of extracellular matrix components
- Detectable levels of granzyme B have been detected in sera from healthy volunteers
- The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.
Compare Similar Items
Show Difference
Antigen: Granzyme B
Applications: Flow Cytometry
Conjugate: FITC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype: IgG1 κ
Purification Method: Affinity Purified
Clone: GB11
Classification: Monoclonal
Host Species: Mouse
Target Species: Human
Immunogen: Human Granzyme B
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Granzyme B
Applications:
Flow Cytometry
Conjugate:
FITC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Clone:
GB11
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Human
Immunogen:
Human Granzyme B
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: H-2D[d]
Applications: Flow Cytometry
Conjugate: FITC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2a κ
Purification Method: Affinity Purified
Clone: 34-2-12
Classification: Monoclonal
Host Species: Mouse
Target Species: Mouse
Immunogen: (C57BL/6 x DBA/2)F1 mouse splenocytes
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
H-2D[d]
Applications:
Flow Cytometry
Conjugate:
FITC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2a κ
Purification Method:
Affinity Purified
Clone:
34-2-12
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Mouse
Immunogen:
(C57BL/6 x DBA/2)F1 mouse splenocytes
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: H-2D[d]
Applications: Flow Cytometry
Conjugate: FITC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype: IgG2a κ
Purification Method: Affinity Purified
Clone: 34-2-12
Classification: Monoclonal
Host Species: Mouse
Target Species: Mouse
Immunogen: (C57BL/6 x DBA/2)F1 mouse splenocytes
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
H-2D[d]
Applications:
Flow Cytometry
Conjugate:
FITC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype:
IgG2a κ
Purification Method:
Affinity Purified
Clone:
34-2-12
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Mouse
Immunogen:
(C57BL/6 x DBA/2)F1 mouse splenocytes
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: H-2Kb
Applications: Flow Cytometry
Conjugate: FITC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Isotype: IgG2a κ
Purification Method: Affinity Purified
Clone: AF6-88.5
Classification: Monoclonal
Host Species: Mouse
Target Species: Mouse
Immunogen: Mouse C57BL splenocytes
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
H-2Kb
Applications:
Flow Cytometry
Conjugate:
FITC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Isotype:
IgG2a κ
Purification Method:
Affinity Purified
Clone:
AF6-88.5
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Mouse
Immunogen:
Mouse C57BL splenocytes
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.