Tyrosine Hydroxylase Recombinant Polyclonal Antibody (9HCLC), Invitrogen™

Description

• This antibody is predicted to react with Monkey and Pig
• Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
• They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
• While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
• The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
• Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine
• In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4)
• BH4 binds to the TH catalytic domain, resulting in enzymatic activity
• Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated
• These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains
• TH is also responsible for the conversion of L-tyrosine to L-dopa
• TH plays a key role in the physiology of adrenergic neurons
• The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.