H3K27cr Recombinant Polyclonal Antibody (9HCLC), ChIP-Verified, Invitrogen™

Description

• This antibody is predicted to react with Rat, Bovine
• Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
• They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
• While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
• The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
• Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells
• H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome
• Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability
• Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors
• The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes
• These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.