Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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CD30/TNFRSF8
1.0 mg/mL
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
Unconjugated
Mouse
Apoptosis, B Cell Development and Differentiation Markers, Cell Cycle and Replication, Embryonic Stem Cell Markers, Immunology, Stem Cell Markers
PBS with No Preservative
943
Recombinant human TNFRSF8 protein
Primary
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Ki-1/779
Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 1 - 2 ug/ml, CyTOF-ready
Monoclonal
Purified
RUO
Human
CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
TNFRSF8
IgG1 κ
Protein A or G purified
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).