7115888

CD197 (CCR7) Monoclonal Antibody (3D12), Super Bright™ 780, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

CD197 (CCR7)

Concentration

5 μL/Test

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Alias

BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC-CKR-7; CCR7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr7; EBI1; Ebi1h; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

Gene Symbols

Ccr7

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Gene

Ccr7

Clone

3D12

Applications

Flow Cytometry

Conjugate

Super Bright 780

Host Species

Rat

Target Species

Human

Gene Accession No.

P32248

Gene ID (Entrez)

1236

Isotype

IgG2a κ

Purification Method

Affinity chromatography

Product Type

Antibody

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Description

  • Description: This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2
  • This cell surface receptor is expressed on activated CD4+ T cell subsets (e.g
  • Th1, Th17, and Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells
  • Due to alternative splicing, CD366 exists as membrane-bound and soluble forms
  • Galectin-9 has been identified as the ligand for CD366
  • In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th17-related cytokines
  • CD366 has also been implicated in tolerance, autoimmune disease (e.g
  • multiple sclerosis), and HIV infection
  • Applications Reported: This F38-2E2 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This F38-2E2 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells
  • This may be used at 5 μL (0.06 μg) per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • Super Bright 780 is a tandem dye that can be excited with the violet laser line (405 nm) and emits at 780 nm
  • We recommend using a 780/60 bandpass filter
  • Please make sure that your instrument is capable of detecting this fluorochrome
  • CCR7 is a member of the G protein coupled receptor family, which is a subfamily of chemokines
  • CCR7 was identified to be induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes
  • CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine
  • CCR7 is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation
  • The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor
  • ESTs have been isolated from blood, embryo, lymph node, and thymus libraries
  • Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen
  • The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.

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Antigen:
CD197 (CCR7)

Concentration:
5 μL/Test

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Alias:
BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC-CKR-7; CCR7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr7; EBI1; Ebi1h; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

Gene Symbols:
Ccr7

Primary or Secondary:
Primary

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Gene:
Ccr7

Clone:
3D12

Applications:
Flow Cytometry

Conjugate:
Super Bright 780

Host Species:
Rat

Target Species:
Human

Gene Accession No.:
P32248

Gene ID (Entrez):
1236

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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