SF3a120/SAP114 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Rabbit, Panda, Orangutan, Monkey, Gorilla, Northern white-cheeked gibbon, Sma This gene encodes subunit 1 of the splicing factor 3a protein complex
• The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing
• Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding
• Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain
• Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs
• Alternative splicing results in multiple transcript variants encoding different isoforms.