7144273
IRS1 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
IRS1
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
Phospho-Insulin Receptor Substrate-1
Gene Symbols
IRS1
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunofluorescence, Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P35568
Gene ID (Entrez)
3667
Immunogen
Between 1192 and 1242
Primary or Secondary
Primary
Content And Storage
4° C
Gene
IRS1
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rabbit, Pig, Gorilla, Chimpanzee and Naked mole rat IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4)
- IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues
- An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo
- Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II
- Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade
- IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
Compare Similar Items
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Antigen: IRS1
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: Phospho-Insulin Receptor Substrate-1
Gene Symbols: IRS1
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Applications: Immunofluorescence, Immunohistochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: P35568
Gene ID (Entrez): 3667
Immunogen: Between 1192 and 1242
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: IRS1
Antigen:
IRS1
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
Phospho-Insulin Receptor Substrate-1
Gene Symbols:
IRS1
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Applications:
Immunofluorescence, Immunohistochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P35568
Gene ID (Entrez):
3667
Immunogen:
Between 1192 and 1242
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
IRS1
Antigen: NRBF2
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: COPR1, COPR2, NRBF-2, comodulator of PPAR and RXR, nuclear receptor binding factor-2, nuclear receptor-binding factor 2
Gene Symbols: __
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Applications: Immunohistochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: Q8VCQ3, Q96F24
Gene ID (Entrez): 29982, 641340
Immunogen: Between 125 and 175
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: NRBF2
Antigen:
NRBF2
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
COPR1, COPR2, NRBF-2, comodulator of PPAR and RXR, nuclear receptor binding factor-2, nuclear receptor-binding factor 2
Gene Symbols:
__
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
Q8VCQ3, Q96F24
Gene ID (Entrez):
29982, 641340
Immunogen:
Between 125 and 175
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
NRBF2
Antigen: CSN5
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: CSN5, JAB1, MGC3149, MOV-34, SGN5
Gene Symbols: __
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Applications: Immunohistochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: O35864, Q92905
Gene ID (Entrez): 10987, 26754
Immunogen: Between 175 and 225
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: COPS5
Antigen:
CSN5
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
CSN5, JAB1, MGC3149, MOV-34, SGN5
Gene Symbols:
__
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
O35864, Q92905
Gene ID (Entrez):
10987, 26754
Immunogen:
Between 175 and 225
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
COPS5
Antigen: CEP131/AZ1
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: 5-azacytidine induced 1, 5-azacytidine-induced protein 1, AZ1, AZI1, centrosomal protein 131 kDa, centrosomal protein 131kDa, KIAA1118, pre-acrosome localization protein 1, ZA1
Gene Symbols: CEP131
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Applications: Immunocytochemistry, Immunofluorescence
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q9UPN4
Gene ID (Entrez): 22994
Immunogen: Between 1033 and 1083
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: CEP131
Antigen:
CEP131/AZ1
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
5-azacytidine induced 1, 5-azacytidine-induced protein 1, AZ1, AZI1, centrosomal protein 131 kDa, centrosomal protein 131kDa, KIAA1118, pre-acrosome localization protein 1, ZA1
Gene Symbols:
CEP131
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Applications:
Immunocytochemistry, Immunofluorescence
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q9UPN4
Gene ID (Entrez):
22994
Immunogen:
Between 1033 and 1083
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
CEP131