ERF Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Horse, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Naked mole rat and L ABT1 (activator of basal transcription 1) is a nuclear protein that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters
• ABT1 associates with TBP in HeLa nuclear extracts in vitro
• Another protein, designated ERF, is a member of the Ets family of transcription factors
• The members of the Ets family are grouped because they share a highly conserved DNA binding domain
• These factors are involved in growth factor pathways and regulate both proliferation and differentiation
• ERF (Ets-2 repressor factor) is a ubiquitously expressed Ets-domain protein that exhibits strong transcriptional repressor activity, suppresses Ets-induced transformation and is regulated by MAPK phosphorylation
• ERF transcription may be regulated by Ets-domain proteins
• Additionally, modulation of ERF activity is involved in the transcriptional regulation of genes activated during entry into G1 phase.