BCAS3 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Orangutan, Monkey, Northern white-cheeked gibbon and Small-eared galago The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers
• Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder
• BCAS3 is thought to be an estrogen receptor (ER)-alpha co-activator that acts through PELP1, another ER-alpha that in turn activates BCAS3 expression
• This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer
• BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.