Notch2 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Monkey, Gorilla, Red-chested mustached tamarin, Northern white-cheeked gibbon, Kloss's gibbon and Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein
• NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types
• NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination
• Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2)
• Alagille syndrome is an autosomal domit multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations
• There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.