7162161
CD366 (TIM3) Monoclonal Antibody (F38-2E2), PE-Cyanine5, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD366 (TIM3)
Concentration
5 μL/Test
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2
Gene Alias
CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3
Gene Symbols
Havcr2
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
Havcr2
Clone
F38-2E2
Applications
Flow Cytometry
Conjugate
PE-Cyanine5
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q8TDQ0
Gene ID (Entrez)
84868
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Description
- Description: This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2
- This cell surface receptor is expressed on activated CD4+ T cell subsets (e.g
- Th1, Th17, and Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells
- Due to alternative splicing, CD366 exists as membrane-bound and soluble forms
- Galectin-9 has been identified as the ligand for CD366
- In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th17-related cytokines
- CD366 has also been implicated in tolerance, autoimmune disease (e.g
- multiple sclerosis), and HIV infection
- Applications Reported: This F38-2E2 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This F38-2E2 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells
- This may be used at 5 μL (0.125 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Light sensitivity: This tandem dye is sensitive to photo-induced oxidation
- Please protect this vial and stained samples from light
- Fixation: Samples can be stored in IC Fixation Buffer (Product No
- TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells
- TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region
- TIM3 is involved in macrophage activation and induction of autoimmune diseases
- Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance
- Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Compare Similar Items
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Antigen: CD366 (TIM3)
Concentration: 5 μL/Test
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2
Gene Alias: CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3
Gene Symbols: Havcr2
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Havcr2
Clone: F38-2E2
Applications: Flow Cytometry
Conjugate: PE-Cyanine5
Host Species: Mouse
Target Species: Human
Gene Accession No.: Q8TDQ0
Gene ID (Entrez): 84868
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD366 (TIM3)
Concentration:
5 μL/Test
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3
Gene Symbols:
Havcr2
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
Havcr2
Clone:
F38-2E2
Applications:
Flow Cytometry
Conjugate:
PE-Cyanine5
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
Q8TDQ0
Gene ID (Entrez):
84868
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD366 (TIM3)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Alias: CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3
Gene Symbols: Havcr2
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Havcr2
Clone: RMT3-23
Applications: Flow Cytometry
Conjugate: PerCP-eFluor 710
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q8VIM0
Gene ID (Entrez): 171285
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD366 (TIM3)
Concentration:
0.2 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Alias:
CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3
Gene Symbols:
Havcr2
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
Havcr2
Clone:
RMT3-23
Applications:
Flow Cytometry
Conjugate:
PerCP-eFluor 710
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
Q8VIM0
Gene ID (Entrez):
171285
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD4
Concentration: 5 μL/Test
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2
Gene Alias: Activation B7-1 antigen, B7, B7.1, B7-1, BB1, B-lymphocyte activation antigen B7, CD28LG, CD28LG1, CD4, CD4 antigen, CD4 antigen (p55), CD4 antigen p55, Cd4 molecule, CD4 precursor, CD4 receptor, CD4, allele 1, cd4a, CD4mut, CD80, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule, cell surface glycoprotein CD4, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, fCD4, L3T4, LAB7, Leu-3, Ly-4, lymphocyte antigen CD4, lymphocyte antigen CD4 precursor, membrane protein, p55, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4), T-lymphocyte activation antigen CD80, W3/25, W3/25 antigen
Gene Symbols: CD4
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: CD4
Clone: RPA-T4
Applications: Flow Cytometry
Conjugate: PerCP-eFluor 710
Host Species: Mouse
Target Species: Human
Gene Accession No.: P01730
Gene ID (Entrez): 920
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD4
Concentration:
5 μL/Test
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
Activation B7-1 antigen, B7, B7.1, B7-1, BB1, B-lymphocyte activation antigen B7, CD28LG, CD28LG1, CD4, CD4 antigen, CD4 antigen (p55), CD4 antigen p55, Cd4 molecule, CD4 precursor, CD4 receptor, CD4, allele 1, cd4a, CD4mut, CD80, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule, cell surface glycoprotein CD4, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, fCD4, L3T4, LAB7, Leu-3, Ly-4, lymphocyte antigen CD4, lymphocyte antigen CD4 precursor, membrane protein, p55, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4), T-lymphocyte activation antigen CD80, W3/25, W3/25 antigen
Gene Symbols:
CD4
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
CD4
Clone:
RPA-T4
Applications:
Flow Cytometry
Conjugate:
PerCP-eFluor 710
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
P01730
Gene ID (Entrez):
920
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD4
Concentration: 5 μL/Test
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias: Activation B7-1 antigen, B7, B7.1, B7-1, BB1, B-lymphocyte activation antigen B7, CD28LG, CD28LG1, CD4, CD4 antigen, CD4 antigen (p55), CD4 antigen p55, Cd4 molecule, CD4 precursor, CD4 receptor, CD4, allele 1, cd4a, CD4mut, CD80, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule, cell surface glycoprotein CD4, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, fCD4, L3T4, LAB7, Leu-3, Ly-4, lymphocyte antigen CD4, lymphocyte antigen CD4 precursor, membrane protein, p55, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4), T-lymphocyte activation antigen CD80, W3/25, W3/25 antigen
Gene Symbols: CD4
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: CD4
Clone: RPA-T4
Applications: Flow Cytometry
Conjugate: Super Bright 600
Host Species: Mouse
Target Species: Human
Gene Accession No.: P01730
Gene ID (Entrez): 920
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD4
Concentration:
5 μL/Test
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias:
Activation B7-1 antigen, B7, B7.1, B7-1, BB1, B-lymphocyte activation antigen B7, CD28LG, CD28LG1, CD4, CD4 antigen, CD4 antigen (p55), CD4 antigen p55, Cd4 molecule, CD4 precursor, CD4 receptor, CD4, allele 1, cd4a, CD4mut, CD80, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule, cell surface glycoprotein CD4, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, fCD4, L3T4, LAB7, Leu-3, Ly-4, lymphocyte antigen CD4, lymphocyte antigen CD4 precursor, membrane protein, p55, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4), T-lymphocyte activation antigen CD80, W3/25, W3/25 antigen
Gene Symbols:
CD4
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Gene:
CD4
Clone:
RPA-T4
Applications:
Flow Cytometry
Conjugate:
Super Bright 600
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
P01730
Gene ID (Entrez):
920
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody