7162991
Tspan-33, Mouse anti-Mouse, Human, FITC, Clone: 29A6.2, Millipore Sigma™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Tspan-33
Applications
Flow Cytometry
Conjugate
FITC
Host Species
Mouse
Research Discipline
Cell Structure
Formulation
Purified mouse monoclonal antibody IgM in PBS with 0.1% sodium azide, with 1.5% BSA.
Gene ID (Entrez)
NP_666285.1
Immunogen
BaF3 cells expressing full-length murine Tspan-33 fused with a Myc-His tag at the C-terminus.
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Clone
29A6.2
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse, Human
Gene Alias
Tetraspanin-33;Penumbra;mPen;Proerythroblast new membrane
Gene Symbols
Tspan33;Pen
Isotype
IgM κ
Purification Method
Protein G purified
Test Specificity
Clone 29A6.2 specifically detects Tspan-33 and targets an epitope with in the extracellular domain.
Description
- Anti-Tspan-33, clone 29A6.2, FITC conjugate, Cat
- No
- MABT911F, is a mouse monoclonal antibody that detects Tetraspanin-33 and has been tested for use in Flow Cytometry
- Tetraspanin-33 (UniProt: Q8R3S2; also known as Tspan-33, Penumbra, mPen, Proerythroblast new membrane) is encoded by the Tspan33 (also known as Pen) gene (Gene ID: 232670) in murine species
- Tetraspanins are evolutionarily conserved proteins and thus far 33 of them have been described in human and murine species
- Tspan-33 is a multi-pass, disulfide-linked homodimeric membrane protein of the tetraspanin (TM4SF) family
- It has been reported that Tspan-33 is highly expressed in activated B cells
- Its expression has also been reported in malignant B cells
- Two isoforms of Tspan-33 have been described that are produced by alternative splicing
- Tspan-33 plays an important role in normal erythropoiesis and in the differentiation of erythroid progenitors
- Tspan-33 contains four transmembrane domains (aa 25-45, 65-85, 97-117, 236-256), three cytoplasmic domains (aa 1-24, 86-96, 257-283), and two extracellular domains (aa 46-64, 118-235)
- Several tetraspanins interact with specific membrane proteins via their second extracellular domain (aa 118-235) and incorporate them into tetraspanin-enriched microdomains to modulate the effectiveness of signal transduction by those membrane proteins
- (Ref.: Luu, VP., et al
- (2013)
- Clin
- Immunol
- 149(3): 388-399).
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Antigen: Tspan-33
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Mouse
Research Discipline: Cell Structure
Formulation: Purified mouse monoclonal antibody IgM in PBS with 0.1% sodium azide, with 1.5% BSA.
Gene ID (Entrez): NP_666285.1
Immunogen: BaF3 cells expressing full-length murine Tspan-33 fused with a Myc-His tag at the C-terminus.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: 29A6.2
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse, Human
Gene Alias: Tetraspanin-33;Penumbra;mPen;Proerythroblast new membrane
Gene Symbols: Tspan33;Pen
Isotype: IgM κ
Purification Method: Protein G purified
Test Specificity: Clone 29A6.2 specifically detects Tspan-33 and targets an epitope with in the extracellular domain.
Antigen:
Tspan-33
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Mouse
Research Discipline:
Cell Structure
Formulation:
Purified mouse monoclonal antibody IgM in PBS with 0.1% sodium azide, with 1.5% BSA.
Gene ID (Entrez):
NP_666285.1
Immunogen:
BaF3 cells expressing full-length murine Tspan-33 fused with a Myc-His tag at the C-terminus.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
29A6.2
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse, Human
Gene Alias:
Tetraspanin-33;Penumbra;mPen;Proerythroblast new membrane
Gene Symbols:
Tspan33;Pen
Isotype:
IgM κ
Purification Method:
Protein G purified
Test Specificity:
Clone 29A6.2 specifically detects Tspan-33 and targets an epitope with in the extracellular domain.
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