7188754
Estrogen Receptor beta Monoclonal Antibody (CO1531), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Estrogen Receptor beta
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; ESR2; ESRB; ESR-BETA; Estrb; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; Estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; Nr3a2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
Gene Symbols
ESR2
Isotype
IgG2a
Purification Method
Protein G
Product Type
Antibody
Clone
CO1531
Applications
Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q92731
Gene ID (Entrez)
2100
Immunogen
This Estrogen Receptor beta antibody was raised against a recombinant protein corresponding to amino acids 212-477 of human Estrogen Receptor beta.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
ESR2
Related Products
Description
- Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described
- Human ER beta was initially cloned and characterized from testis
- Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors
- The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA
- When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins
- There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively)
- Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha
- Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues
- ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
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Antigen: Estrogen Receptor beta
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias: ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; ESR2; ESRB; ESR-BETA; Estrb; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; Estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; Nr3a2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
Gene Symbols: ESR2
Isotype: IgG2a
Purification Method: Protein G
Product Type: Antibody
Clone: CO1531
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human
Gene Accession No.: Q92731
Gene ID (Entrez): 2100
Immunogen: This Estrogen Receptor beta antibody was raised against a recombinant protein corresponding to amino acids 212-477 of human Estrogen Receptor beta.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: ESR2
Antigen:
Estrogen Receptor beta
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias:
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; ESR2; ESRB; ESR-BETA; Estrb; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; Estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; Nr3a2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
Gene Symbols:
ESR2
Isotype:
IgG2a
Purification Method:
Protein G
Product Type:
Antibody
Clone:
CO1531
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
Q92731
Gene ID (Entrez):
2100
Immunogen:
This Estrogen Receptor beta antibody was raised against a recombinant protein corresponding to amino acids 212-477 of human Estrogen Receptor beta.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
ESR2
Antigen: KLF5
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias: (intestinal Kruppel-like factor; 4930520J07Rik; basic transcription element binding protein 2; basic transcription element binding protein BTEB2; Basic transcription element-binding protein 2; Bteb2; BTE-binding protein 2; CKLF; Colon krueppel-like factor; colon kruppel-like factor; GC box binding protein 2; GC-box-binding protein 2; Iklf; Intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; Klf5; Klf5C isoform; Krueppel-like factor 5; Kruppel like factor 5; Kruppel-like factor 5; Kruppel-like factor 5 (intestinal); RP11-505F3.5; Transcription factor BTEB2
Gene Symbols: KLF5
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Clone: __
Applications: ChIP Assay, ChIP sequencing (ChIP-seq), Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: Q13887, Q9Z0Z7
Gene ID (Entrez): 12224, 688
Immunogen: This kLF5 antibody was raised against a peptide derived from the N-terminus of mouse kLF5 (krueppel-like factor 5).
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: KLF5
Antigen:
KLF5
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias:
(intestinal Kruppel-like factor; 4930520J07Rik; basic transcription element binding protein 2; basic transcription element binding protein BTEB2; Basic transcription element-binding protein 2; Bteb2; BTE-binding protein 2; CKLF; Colon krueppel-like factor; colon kruppel-like factor; GC box binding protein 2; GC-box-binding protein 2; Iklf; Intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; Klf5; Klf5C isoform; Krueppel-like factor 5; Kruppel like factor 5; Kruppel-like factor 5; Kruppel-like factor 5 (intestinal); RP11-505F3.5; Transcription factor BTEB2
Gene Symbols:
KLF5
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Clone:
__
Applications:
ChIP Assay, ChIP sequencing (ChIP-seq), Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
Q13887, Q9Z0Z7
Gene ID (Entrez):
12224, 688
Immunogen:
This kLF5 antibody was raised against a peptide derived from the N-terminus of mouse kLF5 (krueppel-like factor 5).
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
KLF5
Antigen: HDAC1
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: antibody with 30% glycerol and 0.035% sodium azide; pH
Gene Alias: DKFZp686H12203; GON-10; HD1; HDAC1; Hdac1-ps; Histone deacetylase 1; histone deacetylase 1-like protein; MommeD5; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; RPD3; RPD3L1
Gene Symbols: HDAC1
Isotype: IgG1
Purification Method: __
Product Type: Antibody
Clone: 10E2
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human, Mouse, Rat
Gene Accession No.: O09106, Q13547, Q4QQW4
Gene ID (Entrez): 297893, 3065, 433759
Immunogen: This HDAC1 antibody was raised against a kLH-conjugated peptide corresponding to amino acids 467-482 of human and murine HDAC1.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: HDAC1
Antigen:
HDAC1
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
antibody with 30% glycerol and 0.035% sodium azide; pH
Gene Alias:
DKFZp686H12203; GON-10; HD1; HDAC1; Hdac1-ps; Histone deacetylase 1; histone deacetylase 1-like protein; MommeD5; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; RPD3; RPD3L1
Gene Symbols:
HDAC1
Isotype:
IgG1
Purification Method:
__
Product Type:
Antibody
Clone:
10E2
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human, Mouse, Rat
Gene Accession No.:
O09106, Q13547, Q4QQW4
Gene ID (Entrez):
297893, 3065, 433759
Immunogen:
This HDAC1 antibody was raised against a kLH-conjugated peptide corresponding to amino acids 467-482 of human and murine HDAC1.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
HDAC1
Antigen: CDKN2A p14ARF
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: Alternative reading frame; ARF; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; Cdkn2a; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; inhibits CDK4; INK4; INK4A; Ink4a/Arf; INK4a-ARF; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; p14 p16; p14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16ink4a; p16-INK4a; P19; P19 TP16; p19; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF
Gene Symbols: CDKN2A
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Clone: __
Applications: Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: P42771, Q8N726
Gene ID (Entrez): 1029
Immunogen: This antibody was raised against a peptide within the N-terminal region of human CDkN2A p14ARF.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: CDKN2A
Antigen:
CDKN2A p14ARF
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
Alternative reading frame; ARF; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; Cdkn2a; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; inhibits CDK4; INK4; INK4A; Ink4a/Arf; INK4a-ARF; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; p14 p16; p14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16ink4a; p16-INK4a; P19; P19 TP16; p19; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF
Gene Symbols:
CDKN2A
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Clone:
__
Applications:
Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
P42771, Q8N726
Gene ID (Entrez):
1029
Immunogen:
This antibody was raised against a peptide within the N-terminal region of human CDkN2A p14ARF.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
CDKN2A